Beertsen W
Angle Orthod. 1979 Jul;49(3):218-24. doi: 10.1043/0003-3219(1979)049<0218:ROCFIT>2.0.CO;2.
Although the rate of turnover of collagen in the periodontal ligament may be somewhat higher than in the gingiva, it is doubtful whether this is the only factor that may explain why rearrangement of collagen fibers in the ligament occurs much more rapidly than in the supra-alveolar region under certain experimental conditions. It may well be that there are other factors that determine the ability of the periodontal tissues to rearrange themselves. On the basis of the distribution pattern of collagen phagocytosis by fibroblasts and the pattern of incorporation of 3H-proline it seems that turnover of collagen, at least in the periodontal ligament is evenly distributed across the width of the tissue. However, local variations in the presence of cells containing intracellular collagen fibrils may occur, as indicated by the observation that a relatively high concentration of ingested collagen fibrils is seen in fibroblasts in the direct vicinity of osteoclasts. It is suggested that coordinated action of fibroblasts and osteoclasts near the alveolar bone surface may represent part of a local mechanism through which rapid remodelling of certain areas in the periodontal ligament may be accomplished.
虽然牙周膜中胶原蛋白的更新率可能略高于牙龈，但在某些实验条件下，韧带中胶原纤维的重排比牙槽嵴以上区域快得多，这是否是唯一的原因仍值得怀疑。很可能还有其他因素决定了牙周组织自我重排的能力。根据成纤维细胞对胶原蛋白的吞噬分布模式以及3H-脯氨酸的掺入模式，至少在牙周膜中，胶原蛋白的更新似乎在组织宽度上均匀分布。然而，含有细胞内胶原纤维的细胞的局部差异可能会出现，如在破骨细胞紧邻区域的成纤维细胞中观察到相对高浓度的摄入胶原纤维所示。有人认为，牙槽骨表面附近的成纤维细胞和破骨细胞的协同作用可能是牙周膜某些区域快速重塑的局部机制的一部分。
