Deporter D A, Svoboda E L, Howley T P, Shiga A
Am J Orthod. 1984 Jun;85(6):519-22. doi: 10.1016/0002-9416(84)90092-7.
The phagocytosis of collagen within soft connective tissues can be used as an index of collagen turnover and remodeling. The objective of this study was to compare the levels of collagen phagocytosis in periodontal and transseptal ligaments in the rat in order to provide an indication of the relative collagen-turnover activities within these two tissues. Periodontal and transseptal ligaments from two rats were examined by the techniques of electron microscope stereology. Parameters quantitated included cytoplasm (CC), extracellular collagen (ECC), and intracellular or phagocytosed collagen (ICC). The results indicated that the cells of the transseptal ligament have significantly more ICC than those of periodontal ligament. This suggests that the transseptal ligament in the rat may have a high rate of collagen turnover. There seems to be an increasing body of evidence, including the present results, that the transseptal ligament region of gingiva has a high level of collagen turnover. It seems likely, therefore, that, unless there are marked species differences in collagen turnover, slow remodeling of the transseptal ligament is not responsible for orthodontic relapse. Why relapse of rotated teeth can be reduced by surgical severing or removal of the transseptal tissue remains to be determined.
软结缔组织中胶原蛋白的吞噬作用可作为胶原蛋白更新和重塑的一个指标。本研究的目的是比较大鼠牙周韧带和牙间韧带中胶原蛋白的吞噬水平，以说明这两种组织中相对的胶原蛋白更新活性。采用电子显微镜体视学技术对两只大鼠的牙周韧带和牙间韧带进行了检查。定量参数包括细胞质（CC）、细胞外胶原蛋白（ECC）和细胞内或吞噬的胶原蛋白（ICC）。结果表明，牙间韧带细胞的ICC明显多于牙周韧带细胞。这表明大鼠的牙间韧带可能具有较高的胶原蛋白更新率。包括本研究结果在内，似乎越来越多的证据表明牙龈的牙间韧带区域具有较高的胶原蛋白更新水平。因此，除非在胶原蛋白更新方面存在明显的物种差异，否则牙间韧带的缓慢重塑不太可能是正畸复发的原因。通过手术切断或切除牙间组织为何能减少旋转牙的复发仍有待确定。
