Kordower J H, Sladek J R, Fiandaca M S, Bing G Y, Gash D M
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, NY 14642.
Brain Res. 1988 Oct 4;461(2):221-9. doi: 10.1016/0006-8993(88)90253-3.
The present study describes a collection of tyrosine hydroxylase-immunoreactive (TH-ir) somata within the subfornical organ (SFO) of the Cebus monkey. In contrast, no cell bodies, and only sparse TH-ir fibers, were observed within the SFO in rats. In the monkey, these TH-ir neurons were observed throughout the rostrocaudal extent of the SFO, preferentially located at its lateral and dorsal aspects. These neurons were bipolar and multipolar with long, beaded, varicose fibers emanating from the cell soma. Cebus monkeys displayed dopamine beta hydroxylase and phenylethanolamine-N-methyltransferase- immunoreactive neurons within established noradrenergic and adrenergic nuclei respectively, but not within the SFO, suggesting that the neurons which are immunoreactive for TH in this region contain dopamine.
本研究描述了卷尾猴穹窿下器官（SFO）内一组酪氨酸羟化酶免疫反应性（TH-ir）胞体。相比之下，在大鼠的SFO内未观察到细胞体，仅观察到稀疏的TH-ir纤维。在猴子中，这些TH-ir神经元在SFO的整个前后范围内均有观察到，优先位于其外侧和背侧。这些神经元为双极和多极神经元，有从细胞体发出的长的、串珠状的、曲张的纤维。卷尾猴在既定的去甲肾上腺素能和肾上腺素能核内分别显示出多巴胺β羟化酶和苯乙醇胺-N-甲基转移酶免疫反应性神经元，但在SFO内未显示，这表明该区域对TH免疫反应的神经元含有多巴胺。
