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Impact of HIV Drug Resistance on HIV/AIDS-Associated Mortality, New Infections, and Antiretroviral Therapy Program Costs in Sub-Saharan Africa.艾滋病毒耐药性对撒哈拉以南非洲地区与艾滋病毒/艾滋病相关的死亡率、新感染率及抗逆转录病毒治疗项目成本的影响
J Infect Dis. 2017 May 1;215(9):1362-1365. doi: 10.1093/infdis/jix089.
2
Field Evaluation of Dried Blood Spots for HIV-1 Viral Load Monitoring in Adults and Children Receiving Antiretroviral Treatment in Kenya: Implications for Scale-up in Resource-Limited Settings.肯尼亚接受抗逆转录病毒治疗的成人和儿童中用于HIV-1病毒载量监测的干血斑现场评估：对资源有限环境下扩大规模的启示
J Acquir Immune Defic Syndr. 2017 Apr 1;74(4):399-406. doi: 10.1097/QAI.0000000000001275.
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Int J Med Inform. 2017 Jan;97:322-330. doi: 10.1016/j.ijmedinf.2016.11.002. Epub 2016 Nov 10.
4
Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study.撒哈拉以南非洲地区一线替诺福韦联合胞嘧啶类似物及奈韦拉平或依非韦伦治疗失败后，人类免疫缺陷病毒1型（HIV-1）对胸腺嘧啶类似物的隐匿性耐药：一项回顾性多中心队列研究
Lancet Infect Dis. 2017 Mar;17(3):296-304. doi: 10.1016/S1473-3099(16)30469-8. Epub 2016 Dec 1.
5
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PLoS One. 2016 Aug 9;11(8):e0160616. doi: 10.1371/journal.pone.0160616. eCollection 2016.
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Antivir Ther. 2015;20(6):655-60. doi: 10.3851/IMP2949. Epub 2015 Mar 4.
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Development of an electronic medical record based alert for risk of HIV treatment failure in a low-resource setting.在资源匮乏环境下开发基于电子病历的HIV治疗失败风险警报。
PLoS One. 2014 Nov 12;9(11):e112261. doi: 10.1371/journal.pone.0112261. eCollection 2014.
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Delayed switch of antiretroviral therapy after virologic failure associated with elevated mortality among HIV-infected adults in Africa.在非洲，艾滋病病毒感染成人中，病毒学失败后延迟转换抗逆转录病毒疗法与死亡率升高相关。
AIDS. 2014 Sep 10;28(14):2097-107. doi: 10.1097/QAD.0000000000000349.

病毒载量检测的扩展及其对人类免疫缺陷病毒耐药性的潜在影响。

Expansion of Viral Load Testing and the Potential Impact on Human Immunodeficiency Virus Drug Resistance.

作者信息

Chun Helen M, Obeng-Aduasare Yaa F, Broyles Laura N, Ellenberger Dennis

机构信息

Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention.

Office of Global Health and HIV, US Peace Corps.

出版信息

J Infect Dis. 2017 Dec 1;216(suppl_9):S808-S811. doi: 10.1093/infdis/jix404.

DOI:10.1093/infdis/jix404
PMID:29029178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5745574/
Abstract

Increasing the volume, strengthening the quality, and proactively using data of human immunodeficiency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (HIVDR) accumulation,and allow for optimal case-based HIVDR surveillance. Triangulation of viral load (VL) and HIVDR testing data could be pursued to answer key questions and translate data and results for program and public policy. Identification of virologic failure and early management mitigates the greater risk of HIVDR. Routine VL monitoring and evaluation systems are necessary, and countries should consider reviewing system requirements, structural needs, and procedural and technical factors for the entire VL cascade, with special emphasis on post-test result use.

摘要

增加人类免疫缺陷病毒（HIV）载量检测的数量、提高质量并积极利用相关数据，对于限制HIV耐药性（HIVDR）积累的威胁至关重要，并有助于开展基于病例的最佳HIVDR监测。可通过对病毒载量（VL）和HIVDR检测数据进行三角测量，以回答关键问题，并将数据和结果转化为项目和公共政策。识别病毒学失败并进行早期管理可降低HIVDR的更大风险。常规的VL监测和评估系统是必要的，各国应考虑审查整个VL检测流程的系统要求、结构需求以及程序和技术因素，特别要重视检测后结果的使用。