病毒载量检测的扩展及其对人类免疫缺陷病毒耐药性的潜在影响。
Expansion of Viral Load Testing and the Potential Impact on Human Immunodeficiency Virus Drug Resistance.
作者信息
Chun Helen M, Obeng-Aduasare Yaa F, Broyles Laura N, Ellenberger Dennis
机构信息
Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention.
Office of Global Health and HIV, US Peace Corps.
出版信息
J Infect Dis. 2017 Dec 1;216(suppl_9):S808-S811. doi: 10.1093/infdis/jix404.
Abstract
Increasing the volume, strengthening the quality, and proactively using data of human immunodeficiency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (HIVDR) accumulation,and allow for optimal case-based HIVDR surveillance. Triangulation of viral load (VL) and HIVDR testing data could be pursued to answer key questions and translate data and results for program and public policy. Identification of virologic failure and early management mitigates the greater risk of HIVDR. Routine VL monitoring and evaluation systems are necessary, and countries should consider reviewing system requirements, structural needs, and procedural and technical factors for the entire VL cascade, with special emphasis on post-test result use.
摘要
增加人类免疫缺陷病毒（HIV）载量检测的数量、提高质量并积极利用相关数据，对于限制HIV耐药性（HIVDR）积累的威胁至关重要，并有助于开展基于病例的最佳HIVDR监测。可通过对病毒载量（VL）和HIVDR检测数据进行三角测量，以回答关键问题，并将数据和结果转化为项目和公共政策。识别病毒学失败并进行早期管理可降低HIVDR的更大风险。常规的VL监测和评估系统是必要的，各国应考虑审查整个VL检测流程的系统要求、结构需求以及程序和技术因素，特别要重视检测后结果的使用。
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