中国非转移性透明细胞肾细胞癌患者肾窦脂肪面积与无进展生存期的关联
The association between renal sinus fat area and the progression-free survival in Chinese non-metastatic clear-cell renal cell carcinoma patients.
作者信息
Huang Haichao, Chen Shi, Yu Wei, Ye Zirong, Li Wei, Xing Jinchun, Wu Xiurong
机构信息
Department of Urology, The First Affiliated Hospital of Xiamen University, Siming District, Xiamen, Fujian 361003, China.
Department of Radiology, The First Affiliated Hospital of Xiamen University, Siming District, Xiamen, Fujian 361003, China.
出版信息
Oncotarget. 2017 Jul 5;8(39):65481-65491. doi: 10.18632/oncotarget.19012. eCollection 2017 Sep 12.
In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.119-0.482; < 0.001) and multivariable (HR: 0.432; 95% CI: 0.369-2.749; = 0.027) analyses. A propensity-score matched (PSM) analysis using Kaplan-Meier curves confirmed our findings (log-rank test; = 0.028). Based on the multivariable analysis, we constructed a prognostic nomogram with 4 factors, namely, RSFA, Fuhrman grade, AJCC stage and sarcomatoid component. The c-index values for the Leibovich scoring system and the nomogram were 0.762 (95%CI, 0.688-0.835) and 0.823 (95%CI, 0.759-0.888), respectively. These findings demonstrate that high RSFA is associated with better progression-free survival in non-metastatic ccRCC.
在这项回顾性研究中，我们评估了268例中国非转移性透明细胞肾细胞癌（ccRCC）患者的肾窦脂肪面积（RSFA）与生存率之间的关联。在单变量分析（风险比[HR]：0.240；95%置信区间[CI]：0.119 - 0.482；P < 0.001）和多变量分析（HR：0.432；95% CI：0.369 - 2.749；P = 0.027）中，RSFA高的患者无进展生存期均优于RSFA低的患者。使用Kaplan-Meier曲线进行的倾向评分匹配（PSM）分析证实了我们的发现（对数秩检验；P = 0.028）。基于多变量分析，我们构建了一个包含4个因素的预后列线图，即RSFA、富尔曼分级、美国癌症联合委员会（AJCC）分期和肉瘤样成分。Leibovich评分系统和列线图的c指数值分别为0.762（95%CI，0.688 - 0.835）和0.823（95%CI，0.759 - 0.888）。这些发现表明，高RSFA与非转移性ccRCC患者更好的无进展生存期相关。
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