Lim Wonbong, Sohn HongMoon, Ko Youngjong, Park Mineon, Kim Bora, Jo Danbi, Jung Jin Seok, Yang Dae Hyeok, Kim Jangho, Kim Ok Joon, Kim Donghwi, Moon Young Lae, Min Jung-Joon, Hyun Hoon
Department of Orthopedic Surgery, Chosun University Hospital, Gwangju 61453, South Korea.
Laboratory of Orthopedic Research, Chosun University Hospital, Gwangju 61453, South Korea.
Oncotarget. 2017 Aug 11;8(39):65770-65777. doi: 10.18632/oncotarget.20187. eCollection 2017 Sep 12.
Tumors of the prostate or breast are particularly likely to metastasize to the bone, and early diagnosis of metastatic bone tumors is important for designing an effective treatment strategy. Imaging modalities for the detection of bone metastasis are limited, and radiation-based techniques are commonly used. Here, we investigated the efficacy of selective near-infrared (NIR) fluorescence detection of metastatic bone tumors and its role in the detection of bone metastasis in prostate and breast cancer cell lines and in a xenograft mouse model. A targeted NIR fluorophore was used to monitor metastatic bone tumors using a NIR fluorescence imaging system in real time, enabling the diagnosis of bone metastasis by providing the location of the metastatic bone tumor. The NIR fluorescence imaging technique using targeted NIR contrast agents is a potential tool for the early diagnosis of bone tumors.
前列腺癌或乳腺癌特别容易转移至骨骼，而转移性骨肿瘤的早期诊断对于制定有效的治疗策略至关重要。用于检测骨转移的成像方式有限，基于辐射的技术较为常用。在此，我们研究了转移性骨肿瘤的选择性近红外（NIR）荧光检测的功效及其在前列腺和乳腺癌细胞系以及异种移植小鼠模型中骨转移检测中的作用。使用靶向近红外荧光团通过近红外荧光成像系统实时监测转移性骨肿瘤，通过提供转移性骨肿瘤的位置来实现骨转移的诊断。使用靶向近红外造影剂的近红外荧光成像技术是骨肿瘤早期诊断的潜在工具。
