Humbert Jana, Will Olga, Peñate-Medina Tuula, Peñate-Medina Oula, Jansen Olav, Both Marcus, Glüer Claus-Christian
Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein Kiel, Kiel University, Am Botanischen Garten 14, 24118 Kiel, Germany.
Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein Kiel, Kiel University, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Photoacoustics. 2020 Oct 1;20:100210. doi: 10.1016/j.pacs.2020.100210. eCollection 2020 Dec.
Few reports quantitatively compare the performance of photoacoustic tomography (PAT) fluorescence molecular tomography (FMT) . We compared both modalities for the detection of signals from injected ICG liposomes in the tibial medullary space of 10 BALB/c mice and . Signals significantly correlated between modalities (R² = 0.69) and within each modality (PAT: R² = 0.70, FMT: R² = 0.76). Phantom studies showed that signals at 4 mm depth are detected down to 3.3 ng ICG by PAT and 33 ng by FMT, with a nominal spatial resolution below 0.5 mm in PAT and limited to 1 mm in FMT. Our study demonstrates comparable sensitivity, but superior sensitivity and resolution for our ICG liposomes of the VevoLAZR the FMT2500. PAT provides a useful new tool for the high-resolution imaging of bone marrow signals, for example for monitoring drug delivery.
很少有报告对光声断层扫描（PAT）和荧光分子断层扫描（FMT）的性能进行定量比较。我们在10只BALB/c小鼠的胫骨骨髓腔中比较了这两种方法对注射的吲哚菁绿（ICG）脂质体信号的检测情况。两种方法之间的信号显著相关（R² = 0.69），并且在每种方法内部也显著相关（PAT：R² = 0.70，FMT：R² = 0.76）。模型研究表明，在4毫米深度处，PAT能检测到低至3.3纳克的ICG信号，FMT能检测到33纳克的ICG信号，PAT的标称空间分辨率低于0.5毫米，FMT则限制在1毫米。我们的研究表明，对于我们的ICG脂质体，VevoLAZR的灵敏度与FMT2500相当，但在灵敏度和分辨率方面更优。PAT为骨髓信号的高分辨率成像提供了一种有用的新工具，例如用于监测药物递送。
