overexpression independent of mutations confers an adverse prognosis in cytogenetically normal acute myeloid leukemia.

The prognostic value of mutations has been systematically investigated in acute myeloid leukemia (AML). However, clinical significance of expressions in AML remains poorly determined. To explore the clinical significance, we analyzed and expressions in 143 AML patients by real-time quantitative PCR. and expressions were significantly up-regulated in AML patients. and mutations were identified in 4% (6/143) and 8% (12/143) of these patients, respectively. However, no significant association was observed between mutations and expressions. High expression was associated with older age, higher white blood cells, and a tendency of higher platelets, whereas high expression was only correlated with older age. Complete remission (CR) rate and overall survival of AML patients were adversely affected by overexpression, but not overexpression. Multivariate analysis revealed that acted as an independent prognostic predictor in cytogenetically normal AML (CN-AML). Moreover, the prognostic value of expression was validated using the published data from Gene Expression Omnibus datasets. In the follow-up patients, expression rather than expression in CR time tended to decrease compared to newly diagnosis time, and both and expressions were significantly increased when in relapse time. Our findings revealed that overexpression and mutations were common events in AML with potential therapeutic target value. overexpression independent of mutations conferred an adverse prognosis in CN-AML.