Pechadre J C, Vernay D, Trolese J F, Bloom M, Dupont P, Rihoux J P
E.E.G. and Functional Exploration of the Nervous System Laboratory, I.N.S.E.R.M. U 195, Clermont Ferrand, France.
Eur J Clin Pharmacol. 1988;35(3):255-9. doi: 10.1007/BF00558262.
The peripheral and central effects of 10 mg cetirizine 2 HCl and 60 mg terfenadine have been compared with placebo in 9 healthy male volunteers. The peripheral effect, in terms of cutaneous reactivity to 1 microgram histamine i.d., was measured by planimetry of the wheal and erythemas. Central effects were assessed with a self-evaluation visual scale and from the results of electroencephalographic spectrum analysis. Peripheral inhibition of histamine reactivity was more intense and quicker for cetirizine than for terfenadine. On the self-evaluation scale, no significant difference between terfenadine, cetirizine and placebo was noted. The quantified EEG did not show any variation in spectral parameters at any time after cetirizine. By contrast, at 6 h terfenadine had increased slow waves and had inhibited the alpha band. Thus, 10 mg cetirizine 2 HCl had less effect on the central nervous system than terfenadine 60 mg, whilst its peripheral action appeared more quickly and was more intense.
在9名健康男性志愿者中，对10毫克盐酸西替利嗪和60毫克特非那定的外周和中枢作用与安慰剂进行了比较。外周作用通过对皮内注射1微克组胺产生的皮肤反应性来衡量，采用风团和红斑面积测量法。中枢作用通过自我评估视觉量表和脑电图频谱分析结果进行评估。西替利嗪对组胺反应性的外周抑制作用比特非那定更强烈、起效更快。在自我评估量表上，特非那定、西替利嗪和安慰剂之间未发现显著差异。定量脑电图显示，服用西替利嗪后任何时间的频谱参数均无变化。相比之下，服用特非那定6小时后，慢波增加，α波受到抑制。因此，10毫克盐酸西替利嗪对中枢神经系统的作用比特非那定60毫克小，但其外周作用起效更快且更强烈。
