El-Gohary Yousef, Abdelhafeez Abdelhafeez, Paton Elizabeth, Gosain Ankush, Murphy Andrew J
Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, TN, 38105, USA.
Pediatr Surg Int. 2018 Jan;34(1):21-27. doi: 10.1007/s00383-017-4196-y. Epub 2017 Oct 13.
Despite hypertrophic pyloric stenosis (HPS) being one of the most frequently treated pediatric surgical conditions, its etiology remains incompletely understood. We review the diagnosis and treatment of this condition with an emphasis on the evolution of surgical techniques that led to laparoscopic pyloromyotomy, the most frequently performed technique for HPS today. In addition, we review key developments in the understanding of HPS etiology and treatment, including the postulated etiology of work-induced hypertrophy of the pylorus, its association with prokinetic macrolide antibiotics, and the emerging role of atropine sulfate as a medical treatment for HPS or a rescue treatment for incomplete myotomy.
尽管肥厚性幽门狭窄（HPS）是最常接受治疗的小儿外科疾病之一，但其病因仍未完全明确。我们回顾了该疾病的诊断和治疗，重点关注导致腹腔镜幽门肌切开术的手术技术演变，这是目前治疗HPS最常用的技术。此外，我们还回顾了在HPS病因和治疗认识方面的关键进展，包括工作引起的幽门肥大的假定病因、其与促动力大环内酯类抗生素的关联，以及硫酸阿托品作为HPS药物治疗或不完全肌切开术补救治疗的新作用。
