婴儿肥厚性幽门狭窄：母亲糖尿病和围产期接触非大环内酯类抗生素。
Infantile hypertrophic pyloric stenosis: maternal diabetes and perinatal exposure to non-macrolide antibiotics.
机构信息
Department of Pediatrics, Shaare Zedek Medical Centre, Jerusalem, Israel.
Clinical Research Center, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
J Perinatol. 2023 Apr;43(4):465-469. doi: 10.1038/s41372-023-01619-2. Epub 2023 Jan 26.
OBJECTIVE
Infant exposure to macrolide antibiotics is a risk factor for infantile hypertrophic pyloric stenosis (IHPS). The aim of the study was to establish whether perinatal exposure to non-macrolide antibiotics was a risk factor for IHPS.
STUDY DESIGN
A retrospective matched case-control study was performed using a database including all children born at Soroka University Medical Centre between 2006 and 2018. Cases and controls were compared using Student T-test and multiple logistic regression.
RESULT
Of 189 461 children in the database, 63 infants were diagnosed with IHPS and underwent pyloromyotomy. There was no association between non-macrolide antibiotic exposure and IHPS. Maternal diabetes (DM) had an adjusted odds ratio for infants developing IHPS of 4.53 (p = 0.004).
CONCLUSION
The lack of association between exposure to non-macrolide antibiotics and IHPS suggests a quality unique to macrolides. An association between DM and IHPS may suggest elevated levels of IGF-1 have a role.
目的
婴儿接触大环内酯类抗生素是婴儿肥厚性幽门狭窄（IHPS）的一个危险因素。本研究旨在确定围产期接触非大环内酯类抗生素是否是 IHPS 的一个危险因素。
研究设计
使用包括 2006 年至 2018 年期间在 Soroka 大学医学中心出生的所有儿童的数据库进行回顾性匹配病例对照研究。使用学生 t 检验和多变量逻辑回归比较病例和对照组。
结果
在数据库中的 189461 名儿童中，有 63 名婴儿被诊断为 IHPS 并接受了幽门肌切开术。非大环内酯类抗生素暴露与 IHPS 之间没有关联。母亲糖尿病（DM）使婴儿患 IHPS 的调整后比值比为 4.53（p=0.004）。
结论
接触非大环内酯类抗生素与 IHPS 之间缺乏关联表明大环内酯类药物具有独特的质量。DM 与 IHPS 之间的关联可能表明 IGF-1 水平升高起作用。
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