口服山奈酚可抑制去卵巢骨质疏松大鼠模型的骨丢失。
Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia.
机构信息
Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.
Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.
出版信息
Pharmacol Rep. 2017 Oct;69(5):1113-1119. doi: 10.1016/j.pharep.2017.05.002. Epub 2017 May 13.
BACKGROUND
Postmenopausal osteoporosis and osteoporotic fractures constitute an increasing problem in developing countries. Kaempferol, isolated from seeds of Cuscuta chinensis, is an active flavonoid inhibiting in vitro osteoclast activity. The aim of the presented research was an assessment of kaempferol effect on estrogen-deficiency-induced bone structure disturbances in rats.
METHODS
The study was performed on 24 Wistar female rats divided into 3 groups: SHAM - rats undergoing a "sham" surgery, OVX-C - control group of animals that underwent ovariectomy, OVX-K - rats undergoing ovariectomy and receiving kaempferol for 8 weeks (from day 56 to day 112).
RESULTS
In the OVX-K group, contrary to the OVX-C one, there was no significant decrease in femoral bone mineral density (BMD). A significant increase in Young's modulus was observed in the OVX-K group compared to the OVX-C (15.33±2.51GPa vs. 11.14±1.93GPa, p<0.05). A decreased bone turnover was detected in the OVX-K group. Tissue volume ratio (BV/TV) and trabecular bone perimeter were increased in the OVX-K group compared to the OVX-C one (0.241±0.037 vs. 0.170±0.022, p<0.05 and 15.52±2.78mm vs. 9.67±3.07mm, p<0.05, respectively).
CONCLUSION
Kaempferol has a beneficial influence on estrogen-deficiency-induced disturbances of bone structure in rats.
背景
绝经后骨质疏松症和骨质疏松性骨折在发展中国家构成了日益严重的问题。山奈酚是从菟丝子种子中分离出来的一种活性类黄酮，能抑制体外破骨细胞活性。本研究旨在评估山奈酚对去势大鼠骨结构紊乱的影响。
方法
本研究共纳入 24 只 Wistar 雌性大鼠，分为 3 组：SHAM 组——接受假手术的大鼠；OVX-C 组——接受卵巢切除术的对照组；OVX-K 组——接受卵巢切除术并给予山奈酚 8 周（第 56 天至第 112 天）的大鼠。
结果
与 OVX-C 组相比，OVX-K 组股骨骨密度（BMD）无明显下降。与 OVX-C 组相比，OVX-K 组杨氏模量显著增加（15.33±2.51GPa 比 11.14±1.93GPa，p<0.05）。OVX-K 组骨转换减少。与 OVX-C 组相比，OVX-K 组组织体积比（BV/TV）和骨小梁周长增加（0.241±0.037 比 0.170±0.022，p<0.05；15.52±2.78mm 比 9.67±3.07mm，p<0.05）。
结论
山奈酚对去势大鼠骨结构紊乱有有益影响。
Zotero 插件