源自肠道黏膜相关T细胞的一种T细胞淋巴瘤类别的鉴定。
Identification of a T cell lymphoma category derived from intestinal-mucosa-associated T cells.
作者信息
Stein H, Dienemann D, Sperling M, Zeitz M, Riecken E O
机构信息
Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, West Germany.
出版信息
Lancet. 1988 Nov 5;2(8619):1053-4. doi: 10.1016/s0140-6736(88)90068-2.
2 cases of precursor T cell lymphoma and 37 cases of peripheral T cell lymphoma were investigated for their reactivity with the monoclonal antibody (mAb) HML-1, which recognises human intestinal T lymphocytes but not lymph-node T cells. In all but one of the lymphomas studied, the tumour cells were unreactive with the mAb HML-1. The HML-1+ lymphoma was the only tumour that was primarily localised in the epithelium and lamina propria of the small intestine, and was associated with ulcerative jejunitis and coeliac disease. This result suggests that the HML-1+ lymphoma was derived from intestinal mucosa T lymphocytes and differs from precursor T cell lymphoblastic lymphomas and nodal and cutaneous peripheral T cell lymphomas.
对2例前体T细胞淋巴瘤和37例外周T细胞淋巴瘤进行了研究，检测它们与单克隆抗体（mAb）HML-1的反应性，该抗体识别人类肠道T淋巴细胞而非淋巴结T细胞。在所研究的淋巴瘤中，除1例之外，其余肿瘤细胞均不与mAb HML-1发生反应。HML-1阳性淋巴瘤是唯一主要局限于小肠上皮和固有层的肿瘤，且与溃疡性空肠炎和乳糜泻相关。这一结果表明，HML-1阳性淋巴瘤源自肠道黏膜T淋巴细胞，不同于前体T细胞淋巴母细胞淋巴瘤以及淋巴结和皮肤外周T细胞淋巴瘤。
Zotero 插件