Narita Zui, Inagawa Takuma, Sueyoshi Kazuki, Lin Crystal, Sumiyoshi Tomiki
Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Front Psychiatry. 2017 Sep 29;8:184. doi: 10.3389/fpsyt.2017.00184. eCollection 2017.
Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region. One month after the last stimulation, there was a significant improvement on cognitive function, measured by the brief assessment of cognition in schizophrenia ( = 0.49). Significant effects were also shown on daily living skills (functional capacity), measured by the UCSD performance-based skills assessment-brief ( = 0.70). Depressive symptoms, measured by the Calgary depression rating scale, as well as psychotic symptoms measured by on the positive and negative syndrome scale positive and general psychopathology subscales also responded to the treatment ( = 0.38, = 0.48, and = 0.50, respectively). This is the first study to suggest that tDCS with the anodal electrode on the left prefrontal cortex improves functional capacity and depressive symptoms in patients with schizophrenia. These results may add to the concept that tDCS provides a strategy to enhance functional outcomes in patients with schizophrenia.
https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018556, UMIN000015953.
近期关于神经调节技术（如经颅直流电刺激[tDCS]）治疗精神分裂症的研究主要集中在精神病性症状上。我们旨在确定重复经颅直流电刺激对改善精神分裂症患者的预后决定因素（如认知功能、日常生活技能和抑郁情绪）是否有效。28名患者连续5天每天接受2次经颅直流电刺激（2毫安×20分钟）。将阳极电极置于左侧背外侧前额叶皮质，阴极电极置于右侧眶上区域。最后一次刺激后1个月，通过精神分裂症认知简短评估测量的认知功能有显著改善（=0.49）。通过基于加州大学圣地亚哥分校表现的技能评估简短版测量的日常生活技能（功能能力）也显示出显著效果（=0.70）。通过卡尔加里抑郁评定量表测量的抑郁症状，以及通过阳性和阴性症状量表的阳性和一般精神病理学分量表测量的精神病性症状也对治疗有反应（分别为=0.38、=0.48和=0.50）。这是第一项表明将阳极电极置于左侧前额叶皮质的经颅直流电刺激可改善精神分裂症患者功能能力和抑郁症状的研究。这些结果可能会进一步支持经颅直流电刺激为改善精神分裂症患者功能预后提供一种策略的观点。
https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018556，UMIN000015953。
