Hosein Farzaei Mohammad, Abbasabadi Zahra, Reza Shams-Ardekani Mohammad, Abdollahi Mohammad, Rahimi Roja
Kermanshah University of Medical Sciences, Kermanshah, Iran; and Department of Pharmacy in Traditional Medicine, Faculty of Traditional Medicine and Persian Medicine, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Kermanshah University of Medical Sciences, Kermanshah, Iran.
Wounds. 2014 Jul;26(7):197-206.
Wound healing is a complex cascade of events with various cellular and biochemical processes that result in reconstruction and regeneration of damaged tissue. The objective of the current study was to scientifically evaluate the medicinal plants said to produce wound healing activity in traditional Iranian medicine (TIM).
Electronic databases were searched for the names of medicinal plants claimed in TIM literature for having wound healing activity. Articles were evaluated to obtain any in vitro, animal, or clinical evidence of their efficacy and possible mechanisms involved in would healing.
Mechanisms of action for some of these plants, including Tamarix spp., Rosa spp., Piper betle, Plantago major, Oxalis spp., Olea europaea, Malva spp., Linum usitatissimum, and Tamarindus indica, have not been yet clarified. In contrast, some herbs such as Vitis vinifera, Quercus spp., Punica granatum, Pinus spp., Polygonum spp., Lilium spp., Gentiana lutea, Arnebia euchroma, Aloe spp., and Caesalpinia spp. have various biological and pharmacological mechanisms that have been verified for wound healing activity.
Overall, TIM resources have introduced various medicinal plants for wounds with confirmed effectiveness according to current pharmacological studies. These herbal remedies could be considered as future drugs for healing of wounds. Further pharmacological and clinical investigations are recommended for exploring safety, exact mechanisms, and efficacy of these herbal remedies. .
伤口愈合是一个复杂的事件级联过程，涉及各种细胞和生化过程，最终导致受损组织的重建和再生。本研究的目的是科学评估在传统伊朗医学（TIM）中据称具有伤口愈合活性的药用植物。
在电子数据库中搜索TIM文献中声称具有伤口愈合活性的药用植物名称。对文章进行评估，以获取其疗效的任何体外、动物或临床证据，以及伤口愈合可能涉及的机制。
其中一些植物，包括柽柳属、蔷薇属、蒌叶、大车前、酢浆草属、油橄榄、锦葵属、亚麻和罗望子的作用机制尚未阐明。相比之下，一些草药，如葡萄、栎属、石榴、松属、蓼属、百合属、黄龙胆、新疆紫草、芦荟属和云实属，具有多种已被证实对伤口愈合有活性的生物学和药理学机制。
总体而言，根据目前的药理学研究，TIM资源已引入多种对伤口有确切疗效的药用植物。这些草药疗法可被视为未来的伤口愈合药物。建议进一步进行药理学和临床研究，以探索这些草药疗法的安全性、确切机制和疗效。
