Laczmanski Lukasz, Lwow Felicja, Osina Anna, Kepska Martyna, Laczmanska Izabela, Witkiewicz Wojciech
1 Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland.
2 Department of Health Promotion, Faculty of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
Tumour Biol. 2017 Oct;39(10):1010428317727164. doi: 10.1177/1010428317727164.
Currently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. The aim of this study was to investigate whether the vitamin D receptor FokI polymorphism is associated with cancerogenesis in sex-dependent cancers. The MEDLINE and ResearchGate databases were used to search for articles up to January 2017, and 96 articles concerning the FokI polymorphism were chosen. Odds ratios with 95% confidence intervals were used to assess the strength of associations between polymorphisms of vitamin D receptor and cancer risk in the described populations. The fixed-effects model and the DerSimonian-Laird random-effects model (with weights based on the inverse variance) were used to calculate summary odds ratios, and both within- and between-study variation were considered. Generally, the F variant reduces the risk of cancer by 4% (odds ratio = 0.96, p value = 0.0057). This effect is particularly evident in female sex-associated cancers (odds ratio = 0.96, 95% confidence interval: 0.93-0.99, p value = 0.0259), but it is not observed in non-sex-associated cancers. Polymorphism FokI is associated with breast and ovarian cancers.
目前，在癌症疾病中观察到较高的发病率和死亡率，尤其是性别相关癌症。许多出版物报道了内源性维生素D浓度在癌症疾病中的积极作用。此外，在携带维生素D受体FokI基因多态性的老年白种人群中，观察到血清维生素D与睾酮浓度之间存在关联。本研究的目的是调查维生素D受体FokI多态性是否与性别相关癌症的发生有关。使用MEDLINE和ResearchGate数据库检索截至2017年1月的文章，选择了96篇关于FokI多态性的文章。使用95%置信区间的比值比来评估所述人群中维生素D受体多态性与癌症风险之间关联的强度。使用固定效应模型和DerSimonian-Laird随机效应模型（权重基于逆方差）来计算汇总比值比，并考虑研究内和研究间的变异。一般来说，F变体使癌症风险降低4%（比值比 = 0.96，p值 = 0.0057）。这种效应在女性相关癌症中尤为明显（比值比 = 0.96，95%置信区间：0.93 - 0.99，p值 = 0.0259），但在非性别相关癌症中未观察到。FokI多态性与乳腺癌和卵巢癌有关。
