Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla 12, Wroclaw, Poland.
Genetics Department, Wroclaw Medical University, Marcinkowskiego 1, Wroclaw, Poland.
Sci Rep. 2019 Nov 5;9(1):16026. doi: 10.1038/s41598-019-52519-5.
The observed increase in morbidity and mortality due to tobacco-related cancers, especially those in the respiratory system and esophagus, is becoming a public health challenge. Smoking cigarettes is one of the main risk factors predisposing individuals to many types of cancers. The aim of this study was to determine the role of select vitamin D receptor (VDR) gene polymorphisms as risk factors in tobacco-related cancers. The MEDLINE and ResearchGate databases were used to search for articles up to June 2017, and 12 articles including 26 studies concerning FokI, ApaI, TaqI and BsmI polymorphisms and lung, neck, head, esophageal and oral cancers were chosen. In total, 5 113 cases and 5 657 controls were included in the pooled analysis. We found a significant relationship between tobacco-related cancers and the occurrence of the "t" allele in the TaqI polymorphism of VDR. The occurrence of the "t" allele reduced the risk of tobacco-related cancers by 17% (OR = 0.83, 0.72-0.96 95% CI, p-value = 0.0114). Our analysis revealed that there is a correlation between the TaqI polymorphism of VDR and the risk of tobacco-related cancers.
观察到与烟草相关的癌症（尤其是呼吸系统和食管癌症）的发病率和死亡率上升，这已成为公共卫生的挑战。吸烟是使个体易患多种癌症的主要危险因素之一。本研究旨在确定选择维生素 D 受体（VDR）基因多态性作为与烟草相关的癌症的风险因素的作用。使用 MEDLINE 和 ResearchGate 数据库搜索截至 2017 年 6 月的文章，选择了 12 篇文章，包括 26 项关于 FokI、ApaI、TaqI 和 BsmI 多态性与肺癌、颈部、头部、食管和口腔癌症的研究。共有 5113 例病例和 5657 例对照纳入汇总分析。我们发现 VDR 的 TaqI 多态性中的“t”等位基因与烟草相关癌症的发生之间存在显著关系。“t”等位基因的发生使烟草相关癌症的风险降低了 17%（OR=0.83，0.72-0.96，95%CI，p 值=0.0114）。我们的分析表明，VDR 的 TaqI 多态性与烟草相关癌症的风险之间存在相关性。
