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从链霉菌属菌株GZWMJZ - 662中分离得到的二波海胺I - O，该链霉菌是来自药食两用植物蕺菜的内生放线菌。

Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

作者信息

Wang Dong-Yang, Li Ming-Xing, Xu Yan-Chao, Fu Peng, Zhu Wei-Ming, Wang Li-Ping

机构信息

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.

Natural Product Research Center of Guizhou Province, Guiyang, 550014, China.

出版信息

Nat Prod Bioprospect. 2025 Jan 6;15(1):9. doi: 10.1007/s13659-024-00494-4.

DOI:10.1007/s13659-024-00494-4
PMID:39760895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11703785/
Abstract

A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1-11). Notably, the newly identified dibohemamines I-O (1-7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet-visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41 μM, respectively.

摘要

对从鱼腥草中分离出的内生放线菌链霉菌属GZWMJZ - 662进行的化学研究，得到了11种波希米亚胺二聚体（1 - 11）。值得注意的是，新鉴定出的二波希米亚胺I - O（1 - 7）此前未见报道。通过详细的光谱分析阐明了它们的结构，包括高分辨率电喷雾电离质谱、核磁共振、红外辐射、紫外可见光谱和电子圆二色光谱。在评估的18种细胞系中，二波希米亚胺I（1）对癌细胞系786 - O和GBC - SD表现出选择性细胞毒性作用，其半抑制浓度值分别为3.24±0.20和7.36±0.41μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/4c706a2a4fbe/13659_2024_494_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/8a0ac9e7bc01/13659_2024_494_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/81133db39d2c/13659_2024_494_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/0b73711e5c9b/13659_2024_494_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/4c706a2a4fbe/13659_2024_494_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/8a0ac9e7bc01/13659_2024_494_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/81133db39d2c/13659_2024_494_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/0b73711e5c9b/13659_2024_494_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/11703785/4c706a2a4fbe/13659_2024_494_Fig4_HTML.jpg

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本文引用的文献

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Anti-cancer Effect and Active Phytochemicals of Houttuynia cordata Thunb. against Human Breast Cancer Cells.鱼腥草对人乳腺癌细胞的抗癌作用及活性植物化学成分。
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