Han Ji-Won, Kim Hongbeom, Youn Joong Kee, Oh Chaeyoun, Jung Sung-Eun, Park Kwi-Won, Lee Seong-Cheol, Kim Hyun-Young
a Department of Pediatric Surgery , Seoul National University Children's Hospital , Seoul , Korea.
Pediatr Hematol Oncol. 2017 May;34(4):212-220. doi: 10.1080/08880018.2017.1354949. Epub 2017 Oct 16.
A lipoblastoma is pathologically benign but often recurs. Due to its rarity, studies are scarce. The purpose of this study was to investigate the clinical characteristics of lipoblastoma occurring in children and to detect any correlations with the expression of Ki-67.
From 1998 to 2010, 33 patients were diagnosed with lipoblastoma at Seoul National University Children's Hospital.
Ki-67 immunohistochemistry staining of the tumor tissue was performed.
A total of 33 patients (64% males) were enrolled in the study, with a mean age of 28 month. Eleven and 22 lesions were deep and superficial, respectively. Complete excisions were performed for 30 patients, and three underwent incomplete excisions. Two patients who underwent incomplete excision subsequently underwent a second operation due to tumor regrowth, and one patient had a recurrence despite complete excision. There was no statistically significant correlation observed between the tumor size or recurrence and the expression of Ki-67.
Lipoblastoma requires an accurate diagnosis and operative resection to alleviate the symptoms induced by its growth. Incompletely resected tumor may regrow; therefore, complete excision is the treatment of choice. Continuous follow-up is needed to monitor for recurrence of disease, even after a complete excision.
脂肪母细胞瘤在病理上是良性的，但常复发。由于其罕见性，相关研究较少。本研究旨在探讨儿童脂肪母细胞瘤的临床特征，并检测其与Ki-67表达的相关性。
1998年至2010年，首尔国立大学儿童医院共诊断出33例脂肪母细胞瘤患者。
对肿瘤组织进行Ki-67免疫组化染色。
本研究共纳入33例患者（64%为男性），平均年龄28个月。分别有11例和22例病变位于深部和浅部。30例患者进行了完整切除，3例进行了不完全切除。2例不完全切除的患者因肿瘤复发随后接受了二次手术，1例患者尽管完整切除仍复发。肿瘤大小或复发与Ki-67表达之间未观察到统计学上的显著相关性。
脂肪母细胞瘤需要准确诊断和手术切除以缓解其生长引起的症状。不完全切除的肿瘤可能复发；因此，完整切除是首选治疗方法。即使在完整切除后，也需要持续随访以监测疾病复发。
