糖基化在衰老发病机制中的作用以及通过草药产品和体育锻炼进行预防。
The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise.
作者信息
Kim Chan-Sik, Park Sok, Kim Junghyun
机构信息
Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Department of Sports Leadership, Kwangwoon University, Seoul, Republic of Korea.
出版信息
J Exerc Nutrition Biochem. 2017 Sep 30;21(3):55-61. doi: 10.20463/jenb.2017.0027.
PURPOSE
Advanced glycation end products (AGEs) are non-enzymatic modifications of proteins or lipids after exposure to sugars. In this review, the glycation process and AGEs are introduced, and the harmful effects of AGEs in the aging process are discussed.
METHODS
Results from human and animal studies examining the mechanisms and effects of AGEs are considered. In addition, publications addressing means to attenuate glycation stress through AGE inhibitors or physical exercise are reviewed.
RESULTS
AGEs form in hyperglycemic conditions and/or the natural process of aging. Numerous publications have demonstrated acceleration of the aging process by AGEs. Exogenous AGEs in dietary foods also trigger organ dysfunction and tissue aging. Various herbal supplements or regular physical exercise have beneficial effects on glycemic control and oxidative stress with a consequent reduction of AGE accumulation during aging.
CONCLUSION
The inhibition of AGE formation and accumulation in tissues can lead to an increase in lifespan.
目的
晚期糖基化终末产物（AGEs）是蛋白质或脂质在接触糖类后发生的非酶促修饰。在本综述中，介绍了糖基化过程和AGEs，并讨论了AGEs在衰老过程中的有害影响。
方法
考虑了来自人类和动物研究中关于AGEs机制和影响的结果。此外，还综述了有关通过AGE抑制剂或体育锻炼减轻糖基化应激方法的出版物。
结果
AGEs在高血糖条件和/或自然衰老过程中形成。大量出版物表明AGEs会加速衰老过程。饮食中的外源性AGEs也会引发器官功能障碍和组织衰老。各种草药补充剂或定期体育锻炼对血糖控制和氧化应激具有有益作用，从而减少衰老过程中AGE的积累。
结论
抑制组织中AGE的形成和积累可延长寿命。
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