Moran M G, Thompson T L, Nies A S
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Am J Psychiatry. 1988 Nov;145(11):1369-78. doi: 10.1176/ajp.145.11.1369.
In their own practices and in consultation, requests to psychiatrists to evaluate and treat sleep disorders in the elderly are common. The five million elders in this country receive 35%-40% of the sedative-hypnotics prescribed, despite the fact that they represent only 12% of the population. Since their sleep disturbances are usually secondary to medical, psychiatric, pharmacologic, or environmental causes, they should receive a thorough evaluation and differential diagnostic approach. Before prescribing a sedative-hypnotic, one should consider nonpharmacologic interventions and education about normal sleep changes due to aging. As a foundation for the judicious prescribing of sedative-hypnotics, the pharmacokinetic changes associated with aging are discussed.
在他们自己的临床实践以及会诊中,向精神科医生提出评估和治疗老年人睡眠障碍的请求很常见。该国五百万老年人所开具的镇静催眠药占比达35% - 40%,尽管他们仅占总人口的12%。由于他们的睡眠障碍通常继发于医学、精神、药物或环境因素,因此应接受全面评估和鉴别诊断。在开具镇静催眠药之前,应考虑非药物干预措施以及关于衰老导致的正常睡眠变化的教育。作为合理开具镇静催眠药的基础,本文讨论了与衰老相关的药代动力学变化。