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韩国精神分裂症患者 n-3 脂肪酸、烟酸、叶酸和维生素 C 饮食摄入不足与精神分裂症饮食指南的制定。

Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in Korean patients with schizophrenia and the development of dietary guidelines for schizophrenia.

机构信息

Department of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea.

Department of Food and Nutrition, Seoul Women's University, Seoul 01797, Republic of Korea.

出版信息

Nutr Res. 2017 Sep;45:10-18. doi: 10.1016/j.nutres.2017.07.001. Epub 2017 Jul 19.

Abstract

Inappropriate dietary intake and poor nutritional status are reported to be associated with metabolic syndrome and psychopathology in patients with schizophrenia. We hypothesized that inappropriate dietary habits and insufficient dietary intake of specific nutrients are associated with schizophrenia. To test the hypothesis, we assessed the dietary habits and nutritional intake of patients with schizophrenia and then developed suitable dietary guidelines. In total, 140 subjects (73 controls and 67 patients with schizophrenia from community mental health centers) were included, and dietary intakes were analyzed using a semi-quantitative food frequency questionnaire. As a result, the proportion of overweight or obese patients was significantly higher in schizophrenia subjects (64.2%) compared with control subjects (39.7%) (P=.004). The male schizophrenia patients had significantly lower dietary intakes of protein, polyunsaturated fatty acids (PUFAs), vitamin K, niacin, folate, and vitamin C than the male control subjects. In all multiple logistic regression models, subjects with the "low" dietary intake of protein, n-3 PUFAs, niacin, folate, and vitamin C had a significantly higher odds ratios for schizophrenia compared with those with the "high" dietary intake category of each nutrient. Therefore, maintenance of a healthy body weight and sufficient dietary intake of protein, PUFAs, niacin, folate, and vitamin C are recommended for Korean patients with schizophrenia.

摘要

不适当的饮食摄入和营养状况不佳与精神分裂症患者的代谢综合征和精神病理学有关。我们假设不适当的饮食习惯和特定营养素的摄入不足与精神分裂症有关。为了验证这一假设,我们评估了精神分裂症患者的饮食习惯和营养摄入情况,然后制定了合适的饮食指南。共有 140 名受试者(73 名对照组和 67 名来自社区心理健康中心的精神分裂症患者)被纳入研究,使用半定量食物频率问卷分析饮食摄入情况。结果显示,精神分裂症患者中超重或肥胖的比例明显高于对照组(64.2%比 39.7%,P=.004)。与男性对照组相比,男性精神分裂症患者的蛋白质、多不饱和脂肪酸(PUFAs)、维生素 K、烟酸、叶酸和维生素 C 的饮食摄入量明显较低。在所有多因素逻辑回归模型中,与高蛋白质、n-3 PUFAs、烟酸、叶酸和维生素 C 饮食摄入组相比,低蛋白质、n-3 PUFAs、烟酸、叶酸和维生素 C 饮食摄入组的精神分裂症发病风险比显著更高。因此,建议韩国精神分裂症患者保持健康的体重和充足的蛋白质、PUFAs、烟酸、叶酸和维生素 C 摄入。

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