Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Sci Rep. 2017 Oct 16;7(1):13262. doi: 10.1038/s41598-017-13650-3.
Metastasis is an important event for cancer evolution and prognosis. In this article, we analyzed the differences in genomic alterations between primary and metastatic tissues at hotspot regions in 15 cancer types and 10,456 samples. Differential somatic mutations at the amino acid, protein domain and gene levels, mutational exclusiveness, and copy number variations were identified in these cancers, while no significant nucleotide and gene fusion differences were detected. The homogeneity and heterogeneity of these differences in cancers were also detected. By characterizing the genomic alterations of these genes, important signaling pathways during metastasis were also identified. In summary, the metastatic cancer tissues retained most genomic features of the primary tumor at the biological level and acquired new signatures during cancer cell migration.
转移是癌症进化和预后的一个重要事件。在本文中，我们分析了 15 种癌症类型和 10456 个样本中热点区域的原发和转移组织之间在基因组改变上的差异。在这些癌症中，鉴定了氨基酸、蛋白质结构域和基因水平的差异体细胞突变、突变排他性和拷贝数变异，而没有检测到显著的核苷酸和基因融合差异。还检测到这些差异在癌症中的同质性和异质性。通过对这些基因的基因组改变进行特征描述，还确定了转移过程中的重要信号通路。总之，转移的癌症组织在生物学水平上保留了原发肿瘤的大多数基因组特征，并在癌细胞迁移过程中获得了新的特征。
