Beta-blocking drugs and psoriasis. A review of cutaneous side effects and retrospective analysis of their effects on psoriasis.

beta-Adrenergic receptor blockers have been prescribed widely since their introduction 20 years ago. Noncardiac indications for beta-blockers have been expanded. Dermatologic manifestations of beta-blockers are reviewed in conjunction with their more liberal use. A retrospective analysis of our experience with beta-blockers in patients with psoriasis is presented. A 1-year study of 588 psoriatic patients who received treatment revealed that 26 patients were taking beta-blockers. Exacerbations of psoriasis were noted in 72.4% of these patients. beta-Blockers may worsen psoriasis and should be carefully evaluated in the management of these patients.