Department of Dermatology, The First Hospital of China Medical University, Heping, Shenyang, Liaoning 110001, P.R. China.
Mol Med Rep. 2017 Dec;16(6):8989-8996. doi: 10.3892/mmr.2017.7759. Epub 2017 Oct 10.
Interleukin (IL)-17 signaling serves an important role in the development and pathogenesis of psoriasis; a chronic skin disease characterized by increased dermal vascularity and the hyperproliferation of keratinocytes. microRNA (miR)‑203 is preferentially expressed in the skin and is an important regulator of keratinocyte differentiation. miR‑203 has been implicated in a number of skin diseases, including psoriasis. However, the role of miR‑203 in IL‑17‑induced vascular endothelial growth factor (VEGF) secretion has yet to be elucidated. The present study demonstrated that miR‑203 expression was upregulated in the ears of IL‑17‑stimulated mice and IL‑17‑treated HaCaT cells. In addition, the IL‑17‑induced increase in miR‑203 expression activated the Janus kinase/signal transducer and activator of transcription signaling pathway and promoted VEGF secretion in HaCaT cells. Furthermore, miR‑203 was observed to bind to the 3'‑untranslated region of suppressor of cytokine signaling 3 (SOCS3) and inhibited SOCS3 expression. The results suggest that miR‑203 expression may be upregulated by IL‑17 stimulation, and miR‑203 is a positive regulator of IL‑17‑induced VEGF secretion. The present study may support potential therapeutic strategies for the treatment of psoriasis.
白细胞介素 (IL)-17 信号在银屑病的发展和发病机制中起重要作用；银屑病是一种慢性皮肤病，其特征是真皮血管增多和角质形成细胞过度增殖。微小 RNA (miR)-203 在皮肤中优先表达，是角质形成细胞分化的重要调节剂。miR-203 已被牵涉到许多皮肤病中，包括银屑病。然而，miR-203 在 IL-17 诱导的血管内皮生长因子 (VEGF) 分泌中的作用尚未阐明。本研究表明，miR-203 在 IL-17 刺激的小鼠耳朵和 IL-17 处理的 HaCaT 细胞中表达上调。此外，IL-17 诱导的 miR-203 表达增加激活了 Janus 激酶/信号转导和转录激活因子信号通路，并促进了 HaCaT 细胞中 VEGF 的分泌。此外，观察到 miR-203 结合到细胞因子信号转导抑制因子 3 (SOCS3) 的 3'非翻译区并抑制 SOCS3 表达。结果表明，miR-203 表达可能被 IL-17 刺激上调，miR-203 是 IL-17 诱导的 VEGF 分泌的正调节剂。本研究可能为治疗银屑病提供潜在的治疗策略。
