非甾体抗炎药预防胆结石复发

Prevention of gallstone recurrence by non-steroidal anti-inflammatory drugs.

作者信息

Hood K, Gleeson D, Ruppin D C, Dowling R H

机构信息

Gastroenterology Unit, UMDS of Guy's Hospital, London.

出版信息

Lancet. 1988 Nov 26;2(8622):1223-5. doi: 10.1016/s0140-6736(88)90812-4.

DOI:10.1016/s0140-6736(88)90812-4

PMID:2903955

Abstract

In laboratory animals, non-steroidal anti-inflammatory drugs (NSAIDs) are reported to inhibit diet-induced gallstone formation. To see if these drugs had a similar effect in man, 82 patients who had taken part in a comparison of ursodeoxycholic acid, placebo, and diet for prevention of gallstone recurrence were sent questionnaires about their use of NSAIDs during the period of the trial. 75 replied. After a mean follow-up of 33 (SEM 4) months none of the 12 regular users of NSAIDs had had gallstone recurrences, compared with 20 of the 63 who never or rarely used these drugs (p less than 0.02).

摘要

据报道，在实验动物中，非甾体抗炎药（NSAIDs）可抑制饮食诱导的胆结石形成。为了观察这些药物在人类中是否有类似作用，对参与熊去氧胆酸、安慰剂和饮食预防胆结石复发比较研究的82例患者，就其在试验期间使用NSAIDs的情况进行问卷调查。75例给予答复。在平均随访33（标准误4）个月后，12例经常使用NSAIDs的患者中无一例出现胆结石复发，而63例从未或很少使用这些药物的患者中有20例出现复发（P<0.02）。