Li Shuangyu, Xiao Yan, Li Qiang, Su Mingzhi, Guo Yuewei, Jin Xin
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 124221, China.
Mar Drugs. 2025 Jan 10;23(1):33. doi: 10.3390/md23010033.
Echinoderms, a diverse group of marine invertebrates including starfish, sea urchins, and sea cucumbers, have been recognized as prolific sources of structurally diverse natural products. In the past five years, remarkable progress has been made in the isolation, structural elucidation, and pharmacological assessment of these bioactive compounds. These metabolites, including polysaccharides, triterpenoids, steroids, and peptides, demonstrate potent bioactivities such as anticancer, anti-inflammatory, antiviral, and antimicrobial effects, providing valuable insights and scaffolds for drug discovery. This review highlights the structural diversity and biological activities of natural products derived from echinoderms over the last five years, with a particular focus on their structure-activity relationships and therapeutic potential. It also outlines the prospects and challenges for future research, aiming to stimulate further exploration in marine drug discovery.
棘皮动物是一类多样的海洋无脊椎动物，包括海星、海胆和海参，它们已被公认为是结构多样的天然产物的丰富来源。在过去五年中，这些生物活性化合物的分离、结构阐明和药理评估取得了显著进展。这些代谢产物，包括多糖、三萜类化合物、类固醇和肽，表现出强大的生物活性，如抗癌、抗炎、抗病毒和抗菌作用，为药物发现提供了有价值的见解和骨架。本综述重点介绍了过去五年中棘皮动物来源天然产物的结构多样性和生物活性，特别关注它们的构效关系和治疗潜力。它还概述了未来研究的前景和挑战，旨在推动海洋药物发现的进一步探索。
