a Departament of Drugs and Medicines , São Paulo State University (UNESP), School of Pharmaceutical Sciences , Araraquara , São Paulo , Brasil.
Crit Rev Anal Chem. 2018 Jan 2;48(1):86-93. doi: 10.1080/10408347.2017.1390425. Epub 2017 Dec 20.
Ursolic acid (UA) is a naturally occurring triterpenoid which is a promising candidate for the development of new therapeutic approaches and for the prevention and treatment of several diseases owing to its pharmacological importance. However, its low solubility in aqueous medium affects its therapeutic application. Several strategies have been used to overcome this obstacle. In this study, the incorporation of UA in to different drug delivery systems was found to be highly efficient. In addition, important investigations were performed about methods for qualitative and quantitative analyses of UA in various raw materials, including plants, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, gas chromatography-mass spectrometry and capillary electrophoresis were used for this purpose. Thus, this review was performed to evaluate the biological effects of UA demonstrated thus far as well as the currently used, delivery systems and analytical methods.
熊果酸（UA）是一种天然存在的三萜类化合物，由于其药理学重要性，它是开发新治疗方法以及预防和治疗多种疾病的有前途的候选药物。然而，其在水介质中的低溶解度影响了其治疗应用。已经使用了几种策略来克服这一障碍。在这项研究中，发现将 UA 掺入到不同的药物输送系统中非常有效。此外，还对各种原材料（包括植物，生物流体和药物输送系统）中 UA 的定性和定量分析方法进行了重要研究。最近，使用高效液相色谱法结合各种检测器，气相色谱-质谱法和毛细管电泳法来进行这方面的研究。因此，进行了这项综述，以评估迄今为止所证明的 UA 的生物学效应，以及目前使用的输送系统和分析方法。
