Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus Mersin 10, Turkey.
Curr Med Chem. 2018;25(37):4866-4875. doi: 10.2174/0929867324666170713102918.
Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy.
熊果酸是一种天然五环三萜，广泛存在于植物和食物中，具有有前景的生物和药理活性。由于其通过不同途径抑制肿瘤细胞的分化、血管生成、侵袭和转移，且毒性低，该化合物一直受到研究人员的关注。由于该化合物在水中的溶解度差，熊果酸的生物利用度较差。熊果酸的生物利用度低、血浆半衰期短以及在体内的非特异性分布被认为是该化合物治疗开发的障碍。纳米药物递送系统可以提高一些药物的药代动力学、生物利用度和治疗活性。本综述重点介绍了熊果酸纳米药物递送系统在癌症治疗方面的最新进展。
