重度子痫前期与正常妊娠孕妇及脐血中的亲环素A及其与维生素D和锌的相关性
Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc.
作者信息
Wibowo Noroyono, Kurniawan Riyan Hari, Irwinda Rima, Prameswari Natasya
机构信息
a Fetomaternal Division, Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
b Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
出版信息
Hypertens Pregnancy. 2017 Nov;36(4):283-287. doi: 10.1080/10641955.2017.1385792. Epub 2017 Oct 17.
OBJECTIVE
To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
METHODS
We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014.
RESULTS
Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853).
CONCLUSION
Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.
目的
研究重度子痫前期孕妇及脐血中环孢素A水平，并与正常妊娠进行比较，探讨其与维生素D及锌水平的相关性。
方法
我们对2014年1月至4月在西托·曼古库苏莫医院分娩的孕妇进行了一项横断面观察性研究。
结果
共纳入39名受试者。与血压正常的妊娠相比，重度子痫前期患者血清中环孢素A水平更高（1299.60对1039.50；p=0.017）。母体环孢素A、维生素D和锌之间的相关性无统计学意义（p=0.189和p=0.853）。
结论
重度子痫前期患者的环孢素A水平高于正常妊娠。环孢素A、锌和维生素D之间无相关性。
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