Ponnudhali D, Nandhini N E
Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College and Hospitals, Vinayaka Mission's Research Foundation (DU), NH-47, Seeragapadi, Salem, Tamil Nadu 636308 India.
Department of Biochemistry, Swamy Vivekanandha Medical College Hospital and Research Institute, Tiruchengode, Tamil Nadu 637205 India.
J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):376-382. doi: 10.1007/s13224-024-02008-1. Epub 2024 Jul 3.
Serum Cyclophilin A (CyPA) is a 20 KD chaperone protein, secreted in response to oxidative stress and has an important role as mediator of inflammation. CyPA has been related to Preeclampsia (PE) and implicated as its potential biomarker.
To analyze serum Cyclophilin A levels in preeclamptic women and compare it with healthy pregnant women, in South India. We aimed to look for its validity as a predictive biomarker for PE.
This is a prospective cohort study, conducted in pregnant women attending the OPD of a private medical college hospital in Salem. Maternal serum CyPA levels were assessed in PE and healthy pregnant women in their 2nd trimester (20-26 weeks) and repeated again in the 3rd trimester of PE women.
Among 120 pregnant women recruited for the study, 60 were preeclamptic and 60 were healthy pregnant women. Higher serum CyPA levels were observed in PE group (34.58 ± 5.53 ng/ml), compared to healthy pregnant women (7.41 ± 7.7 ng/ml), < 0.001. CyPA also had good discriminating ability between PE & healthy pregnancy, (AUC = 0.971, 95% CI 0.932-1.00), with high sensitivity (98.33%)and specificity (98.33%).
CyPA levels were markedly increased in preeclampsia, and could be a novel biomarker of preeclampsia.
血清亲环素A（CyPA）是一种20千道尔顿的伴侣蛋白，在氧化应激反应中分泌，作为炎症介质发挥重要作用。CyPA与子痫前期（PE）相关，并被认为是其潜在的生物标志物。
分析印度南部子痫前期妇女的血清亲环素A水平，并与健康孕妇进行比较。我们旨在探讨其作为PE预测生物标志物的有效性。
这是一项前瞻性队列研究，在塞勒姆一家私立医学院医院门诊部就诊的孕妇中进行。在孕中期（20 - 26周）评估PE患者和健康孕妇的母血清CyPA水平，并在PE患者的孕晚期再次评估。
在招募的120名孕妇中，60例子痫前期患者和60例健康孕妇。与健康孕妇（7.41±7.7纳克/毫升）相比，PE组血清CyPA水平更高（34.58±5.53纳克/毫升），P<0.001。CyPA在PE与健康妊娠之间也具有良好的鉴别能力，（曲线下面积=0.971，95%可信区间0.932 - 1.00），敏感性高（98.33%），特异性高（98.33%）。
子痫前期患者CyPA水平显著升高，可能是子痫前期的一种新型生物标志物。
