Pogodaev Aleksandr A, Wong Albert S Y, Huck Wilhelm T S
Institute for Molecules and Materials, Radboud University, Nijmegen , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
J Am Chem Soc. 2017 Nov 1;139(43):15296-15299. doi: 10.1021/jacs.7b08109. Epub 2017 Oct 19.
Systems chemistry aims to emulate the functional behavior observed in living systems by constructing chemical reaction networks (CRNs) with well-defined dynamic properties. Future expansion of the complexity of these systems would require external control to tune behavior and temporal organization of such CRNs. In this work, we design and implement a photolabile probe, which upon irradiation strengthens the negative feedback loop of a CRN that produces oscillations of trypsin under out-of-equilibrium conditions. By changing the timing and duration of irradiation, we can tailor the temporal response of the network.
系统化学旨在通过构建具有明确动态特性的化学反应网络（CRN）来模拟在生命系统中观察到的功能行为。这些系统未来复杂性的扩展将需要外部控制来调节此类CRN的行为和时间组织。在这项工作中，我们设计并实现了一种光不稳定探针，该探针在照射后会加强一个CRN的负反馈回路，该回路在非平衡条件下产生胰蛋白酶振荡。通过改变照射的时间和持续时间，我们可以调整网络的时间响应。
