用于癌症治疗的具有高效药物递送和释放功能的无载体纳米药物：从固有物理化学性质到外部修饰

Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification.

作者信息

Mei Heng, Cai Shengsheng, Huang Dennis, Gao Huile, Cao Jun, He Bin

机构信息

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78731, USA.

出版信息

Bioact Mater. 2021 Jul 6;8:220-240. doi: 10.1016/j.bioactmat.2021.06.035. eCollection 2022 Feb.

DOI:10.1016/j.bioactmat.2021.06.035

PMID:34541398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8424425/

Abstract

The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering "all-in-one" functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment.

摘要

由于无载体纳米药物具有高载药能力、制备方法简单以及提供“一体化”功能平台特性，其已取得了显著发展。然而，无载体纳米药物的固有缺陷限制了它们在整个过程中的递送和释放行为，这显著损害了治疗效果并阻碍了它们在癌症治疗中的进一步发展。在本综述中，我们总结并讨论了近期用于改善癌症治疗的增强无载体纳米药物递送和释放的策略，包括优化其内在物理化学性质和进行外部修饰。最后，讨论了无载体纳米药物面临的相应挑战，并提出了其应用的未来前景。我们希望本综述将为合理设计更有效的无载体纳米药物以推进治疗提供建设性信息。