Abraham W C, Kairiss E W
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neurosci Lett. 1988 Jun 17;89(1):36-42. doi: 10.1016/0304-3940(88)90477-6.
The N-methyl-D-aspartate receptor antagonist D,L-2-amino-5-phosphonopentanoate (2AP5) was administered intraventricularly to determine its effect on the complex spike firing pattern of spontaneously active hippocampal pyramidal cells recorded in urethane anaesthetized rats. Following 2AP5 delivery, complex spike firing decreased by a mean 36%, while only a 5% decrease was observed after saline injection. This effect could not be explained by changes in firing rate per se but appeared to be related to the degree of blockade of commissurally induced long-term potentiation. Thus 2AP5 not only disrupts synaptic plasticity in the hippocampus but can also alter the pattern of ongoing activity of the pyramidal cells.
将N-甲基-D-天冬氨酸受体拮抗剂D,L-2-氨基-5-膦酰基戊酸（2AP5）经脑室注射，以确定其对在乌拉坦麻醉大鼠中记录的自发活动海马锥体细胞复合锋电位发放模式的影响。注射2AP5后，复合锋电位发放平均减少了36%，而注射生理盐水后仅观察到5%的减少。这种效应不能用发放率本身的变化来解释，而似乎与联合诱导的长时程增强的阻断程度有关。因此，2AP5不仅破坏海马中的突触可塑性，还能改变锥体细胞的持续活动模式。
