Lucinda Leda M F, Aarestrup Beatriz J V, Reboredo Maycon M, Pains Thais D A, Chaves Raphael Z, Reis João E P, Louzada Mário J Q, Guerra Martha O
Centro de Biologia da Reprodução, Universidade Federal de Juiz de Fora/UFJF, São Pedro, Caixa Postal 328, 36001-970 Juiz de Fora, MG, Brazil.
Faculdade de Medicina, Universidade Federal de Juiz de Fora/UFJF, Avenida Eugênio do Nascimento, s/n, Caixa Postal 328, 36001-970 Juiz de Fora, MG, Brazil.
An Acad Bras Cienc. 2017 Oct-Dec;89(4):2833-2841. doi: 10.1590/0001-3765201720160479. Epub 2017 Oct 16.
Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.
评估银杏叶提取物对糖皮质激素诱导的骨质疏松大鼠骨碱性磷酸酶、骨密度及胫骨力学性能的影响。骨质疏松诱导后，将大鼠分为五组：骨质疏松组；EGb1（28毫克/千克）；EGb2（56毫克/千克）；阿仑膦酸钠（0.2毫克/只动物）和对照组。动物接受治疗20天和30天。对照组与骨质疏松组进行比较（采用学生t检验），而其他组通过方差分析，随后进行Tukey/Dunnett'T3检验（p<0.05）。骨质疏松组的骨碱性磷酸酶、骨密度、骨硬度、最大负荷和弹性均降低。EGb1和EGb2组（30天）的骨碱性磷酸酶值升高。此外，EGb2组和阿仑膦酸钠组（20天和30天）的骨密度增加。银杏叶提取物使用双能X线吸收法恢复了骨碱性磷酸酶和骨密度。
