EA 4708 I3MTO Laboratory, Orleans University, 45067 Orleans, France.
Translational Medicine Research Platform, PRIMMO, Regional Hospital of Orleans, 45007 Orleans, France.
Int J Mol Sci. 2021 Dec 29;23(1):377. doi: 10.3390/ijms23010377.
Clinical and experimental data have shown that prolonged exposure to GCs leads to bone loss and increases fracture risk. Special attention has been given to existing emerging drugs that can prevent and treat glucocorticoid-induced osteoporosis GIOP. However, there is no consensus about the most relevant animal model treatments on GIOP. In this systematic review, we aimed to examine animal models of GIOP centering on study design, drug dose, timing and size of the experimental groups, allocation concealment, and outcome measures. The present review was written according to the PRISMA 2020 statement. Literature searches were performed in the PubMed electronic database via Mesh with the publication date set between April, 2011, and February 2021. A total of 284 full-text articles were screened and 53 were analyzed. The most common animal species used to model GIOP were rats (66%) and mice (32%). In mice studies, males (58%) were preferred and genetically modified animals accounted for 28%. Our work calls for a standardization of the establishment of the GIOP animal model with better precision for model selection. A described reporting design, conduction, and selection of outcome measures are recommended.
临床和实验数据表明，长期暴露于糖皮质激素会导致骨质流失，增加骨折风险。人们特别关注现有的新兴药物，这些药物可以预防和治疗糖皮质激素诱导的骨质疏松症（GIOP）。然而，对于 GIOP 最相关的动物模型治疗方法，尚未达成共识。在本系统评价中，我们旨在研究以研究设计、药物剂量、实验组的时间和规模、分配隐匿和结果测量为中心的 GIOP 动物模型。本综述是根据 PRISMA 2020 声明编写的。通过使用 Mesh 在 PubMed 电子数据库中进行文献检索，检索时间范围为 2011 年 4 月至 2021 年 2 月。共筛选出 284 篇全文文章，并对 53 篇进行了分析。用于模拟 GIOP 的最常见动物物种是大鼠（66%）和小鼠（32%）。在小鼠研究中，雄性（58%）更为常见，且遗传修饰动物占 28%。我们的工作呼吁对 GIOP 动物模型的建立进行标准化，以实现更好的模型选择精度。建议描述报告设计、实施和结果测量的选择。
