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日本长野县松本市银屑病患者的流行病学调查。

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan.

机构信息

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

出版信息

J Dermatol. 2018 Mar;45(3):314-317. doi: 10.1111/1346-8138.14101. Epub 2017 Oct 19.

Abstract

A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84.0%), vitamin D analogs (61.5%), and a combination of calcipotriol and betamethasone dipropionate (31.0%). Current systemic treatments included cyclosporin (9.0%), etretinate (7.4%) and methotrexate (1.3%). Biologic treatments included adalimumab (4.0%), ustekinumab (2.7%), infliximab (1.3%) and secukinumab (0.8%). Ultraviolet B therapy (11.3%) was the predominant phototherapy in which narrow band ultraviolet B therapy accounted for the majority, followed by psoralen and ultraviolet A therapy (1.0%). According to the recent evolution of psoriasis treatment, the use of biologics has been increasing. This study demonstrates the changes of treatment trends of psoriasis in a non-metropolitan regional area.

摘要

一项针对日本长野县松本市的银屑病的局部流行病学调查于 2016 年 2 月 19 日至 6 月 30 日进行。患者主要为男性(268 例,71.5%男性对 107 例,28.5%女性)。我们估计松本市地区的银屑病患病率为 0.097%。确定的银屑病临床类型包括寻常型银屑病(90.7%)、银屑病关节炎(5.9%)、脓疱型银屑病(2.1%)、点滴状银屑病(1.0%)和红皮病型银屑病(0.3%)。局部治疗药物包括皮质类固醇(84.0%)、维生素 D 类似物(61.5%)和卡泊三醇与倍他米松二丙酸酯的联合制剂(31.0%)。目前的系统治疗包括环孢素(9.0%)、阿维 A 酯(7.4%)和甲氨蝶呤(1.3%)。生物治疗包括阿达木单抗(4.0%)、乌司奴单抗(2.7%)、英夫利昔单抗(1.3%)和司库奇尤单抗(0.8%)。紫外线 B 疗法(11.3%)是主要的光疗方法,其中窄带紫外线 B 疗法占大多数,其次是光化学疗法和 UVA 疗法(1.0%)。根据银屑病治疗的最新进展,生物制剂的使用正在增加。本研究展示了非大都市地区银屑病治疗趋势的变化。

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