Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
J Dermatol. 2018 Mar;45(3):314-317. doi: 10.1111/1346-8138.14101. Epub 2017 Oct 19.
A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84.0%), vitamin D analogs (61.5%), and a combination of calcipotriol and betamethasone dipropionate (31.0%). Current systemic treatments included cyclosporin (9.0%), etretinate (7.4%) and methotrexate (1.3%). Biologic treatments included adalimumab (4.0%), ustekinumab (2.7%), infliximab (1.3%) and secukinumab (0.8%). Ultraviolet B therapy (11.3%) was the predominant phototherapy in which narrow band ultraviolet B therapy accounted for the majority, followed by psoralen and ultraviolet A therapy (1.0%). According to the recent evolution of psoriasis treatment, the use of biologics has been increasing. This study demonstrates the changes of treatment trends of psoriasis in a non-metropolitan regional area.
一项针对日本长野县松本市的银屑病的局部流行病学调查于 2016 年 2 月 19 日至 6 月 30 日进行。患者主要为男性（268 例，71.5%男性对 107 例，28.5%女性）。我们估计松本市地区的银屑病患病率为 0.097%。确定的银屑病临床类型包括寻常型银屑病（90.7%）、银屑病关节炎（5.9%）、脓疱型银屑病（2.1%）、点滴状银屑病（1.0%）和红皮病型银屑病（0.3%）。局部治疗药物包括皮质类固醇（84.0%）、维生素 D 类似物（61.5%）和卡泊三醇与倍他米松二丙酸酯的联合制剂（31.0%）。目前的系统治疗包括环孢素（9.0%）、阿维 A 酯（7.4%）和甲氨蝶呤（1.3%）。生物治疗包括阿达木单抗（4.0%）、乌司奴单抗（2.7%）、英夫利昔单抗（1.3%）和司库奇尤单抗（0.8%）。紫外线 B 疗法（11.3%）是主要的光疗方法，其中窄带紫外线 B 疗法占大多数，其次是光化学疗法和 UVA 疗法（1.0%）。根据银屑病治疗的最新进展，生物制剂的使用正在增加。本研究展示了非大都市地区银屑病治疗趋势的变化。
