Hu Jingjin, Lu Wenhua, Li Xingyu, Yang Jing, Tan Minjia, Hu Kun, Wang Qiaolin, Deng Sichun, Liu Yijie, Chen Junchen, Zhu Wu, Kuang Yehong
The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
Front Microbiol. 2022 Aug 10;13:937666. doi: 10.3389/fmicb.2022.937666. eCollection 2022.
Psoriasis can be provoked or exacerbated by environmental exposures such as certain microbiomes. The distinction between plaque psoriasis (PP) and guttate psoriasis (GP) in the skin or pharyngeal microbiota is not yet clear. High-throughput sequencing using Illumina MiSeq was used in this study to characterize skin and pharyngeal microbial composition in patients with PP [large PP (LPP, = 62), small PP (SPP, = 41)] and GP ( = 14). The alpha- and beta-diversity of skin microbiota LPP was similar to that of the SPP group, but different from the GP group. There were no differences in pharyngeal microbiota among the groups. According to linear discriminant analysis effect size (LEfSe) analysis, , , , , and --- were the dominant genera of skin microbiota in PP. Diversity of skin microbiota correlated with Psoriasis Area and Severity Index (PASI). Moderate-to-severe psoriasis and mild psoriasis have different microbiota compositions. The skin microbiota may be related to the pharyngeal microbiota. Furthermore, two microbiota-based models could distinguish psoriasis subtypes with area under the receiver-operating characteristic curve (AUC-ROC) of 0.935 and 0.836, respectively. In conclusion, the skin microbiota in patients with LPP is similar to that in patients with SPP, but displays variations compared to that of GP, no differences are noted between subtypes in pharyngeal microbiota. Skin microbiota diversity correlated with PASI.
银屑病可能会由某些微生物群等环境暴露因素引发或加重。皮肤或咽部微生物群中斑块状银屑病（PP）和点滴状银屑病（GP）之间的区别尚不清楚。本研究采用Illumina MiSeq进行高通量测序，以表征PP患者[大面积PP（LPP，n = 62）、小面积PP（SPP，n = 41）]和GP患者（n = 14）的皮肤和咽部微生物组成。LPP组皮肤微生物群的α-多样性和β-多样性与SPP组相似，但与GP组不同。各组之间咽部微生物群没有差异。根据线性判别分析效应大小（LEfSe）分析，……、……、……、……和……是PP患者皮肤微生物群的优势菌属。皮肤微生物群的多样性与银屑病面积和严重程度指数（PASI）相关。中度至重度银屑病和轻度银屑病具有不同的微生物群组成。皮肤微生物群可能与咽部微生物群有关。此外，两种基于微生物群的模型能够区分银屑病亚型，受试者操作特征曲线下面积（AUC-ROC）分别为0.935和0.836。总之，LPP患者的皮肤微生物群与SPP患者相似，但与GP患者相比存在差异，各亚型之间咽部微生物群未观察到差异。皮肤微生物群多样性与PASI相关。
