Meng Jing, Chen Xiujin, Tian Yang, Li Zhongfeng, Zheng Qingfeng
Department of Chemistry, Beijing Key Laboratory for Optical Materials and Photonic Devices, Capital Normal University, Haidian District, Beijing, 100048, P.R. China.
Department of Thoracic Surgery, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, 100021, P.R. China.
Chemistry. 2017 Dec 11;23(69):17521-17530. doi: 10.1002/chem.201702573. Epub 2017 Nov 15.
Imaging-guided photothermal therapy (PTT) provides an attractive way to treat cancer. A composite material of a nanoscale metal-organic framework (NMOF) and graphene oxide (GO) has been prepared for potential use in tumor-guided PTT with magnetic resonance imaging (MRI). The NMOFs containing Fe were prefabricated with an octahedral morphology through a solvothermal reaction to offer a strong T -weighted contrast in MRI. Then the NMOFs were decorated with GO nanosheets, which had good photothermal properties. After decoration, zeta-potential characterization shows that the aqueous stability of the composite material is enhanced, UV/Vis and near-infrared (NIR) spectra confirm that NIR absorption is also increased, and photothermal experiments reveal that the composite materials express higher photothermal conversion effects and conversion stability. The fabricated NMOF/GO shows low cytotoxicity, effective T -weighted contrast of MRI, and positive PTT behavior for a tumor model in vitro. The performance of the composite NMOF/GO for MRI and PTT was also tested upon injection into A549 tumor-bearing mice. The studies in vivo revealed that the fabricated NMOF/GO was efficient in T -weighted imaging and ablation of the A549 tumor with low cytotoxicity, which implied that the prepared composite contrast agent was a potential multifunctional nanotheranostic agent.
成像引导光热疗法（PTT）为癌症治疗提供了一种有吸引力的方法。已制备了一种纳米级金属有机框架（NMOF）与氧化石墨烯（GO）的复合材料，用于磁共振成像（MRI）引导的肿瘤PTT。通过溶剂热反应预制了具有八面体形态的含Fe的NMOF，以在MRI中提供强T加权对比度。然后用具有良好光热性能的GO纳米片对NMOF进行修饰。修饰后，zeta电位表征表明复合材料的水稳定性增强，紫外/可见和近红外（NIR）光谱证实近红外吸收也增加，光热实验表明复合材料表现出更高的光热转换效应和转换稳定性。制备的NMOF/GO对体外肿瘤模型显示出低细胞毒性、有效的MRI T加权对比度和积极的PTT行为。将复合NMOF/GO注射到荷A549肿瘤小鼠体内后，还测试了其对MRI和PTT的性能。体内研究表明，制备的NMOF/GO在T加权成像和消融A549肿瘤方面有效，且细胞毒性低，这意味着所制备的复合造影剂是一种潜在的多功能纳米诊疗剂。
