Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.
Angew Chem Int Ed Engl. 2017 Dec 11;56(50):15802-15804. doi: 10.1002/anie.201708940. Epub 2017 Oct 19.
Pd at the crossroads: The palladium-catalyzed cross-coupling of nitroarenes has eluded chemists for decades. Recently, the first palladium-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings of nitroarenes were reported. Mechanistically, this process involves the challenging oxidative addition of LPd into the Ar-NO bond. This process features a broad substrate scope with respect to both the nitroarene and the nucleophilic coupling partners.
硝基芳烃的钯催化交叉偶联反应几十年来一直困扰着化学家。最近，首次报道了硝基芳烃的钯催化 Suzuki-Miyaura 和 Buchwald-Hartwig 交叉偶联反应。从机理上讲，该过程涉及 LPd 向 Ar-NO 键的挑战性氧化加成。该过程具有广泛的底物范围，包括硝基芳烃和亲核偶联试剂。
