Chelyapov N V, Antonova T P, Yanova N N, Chernos V I
Moscow Research Institute of Viral Preparations, U.S.S.R. Ministry of Health.
Acta Virol. 1988 Sep;32(5):409-16.
Immunologic properties of vaccinia virus (VV), strain LIPV, and VV recombinant strains containing the gene of hepatitis B virus surface antigen and the TK gene of herpes simplex virus (HSV) have been studied. Production of antibodies against the majority of VV structural proteins, including nucleocapsid internal proteins was demonstrated in rabbits. Insertion of heterologous genes into the VV genome was without effect on the spectrum of antibodies produced against VV virion proteins. The data obtained in volunteers indicate that not only virus-neutralizing antibodies but also antibodies against most VV structural proteins are preserved in humans over many years. Reimmunization of volunteers with VV recombinant stimulates synthesis of antibodies against virion proteins whereas the spectrum of antibodies remains unchanged. Humans and rabbits did not differ in the spectrum of antibodies to VV virion proteins.
已对痘苗病毒（VV）LIPV株以及含有乙型肝炎病毒表面抗原基因和单纯疱疹病毒（HSV）TK基因的VV重组株的免疫学特性进行了研究。在兔体内证实产生了针对包括核衣壳内部蛋白在内的大多数VV结构蛋白的抗体。将异源基因插入VV基因组对针对VV病毒粒子蛋白产生的抗体谱没有影响。在志愿者身上获得的数据表明，不仅病毒中和抗体，而且针对大多数VV结构蛋白的抗体在人体内多年来都得以保留。用VV重组体对志愿者进行再次免疫可刺激针对病毒粒子蛋白的抗体合成，而抗体谱保持不变。人类和兔在针对VV病毒粒子蛋白的抗体谱方面没有差异。
