Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, Canada ON M5G 1X5.
Department of Molecular Genetics, University of Toronto, Toronto, Canada ON M5S 1A8.
Glycobiology. 2017 Jul 1;27(7):595-598. doi: 10.1093/glycob/cwx035.
Pedersen et al. (Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, et al. 2016. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 535: 376-381.) report that human serum levels of branched-chain amino acids (BCAA) and N-acetylglucosamine (GlcNAc) increase in proportion to insulin resistance. They focus on the microbiome and the contributing subset of microbe species, thereby demonstrating disease causality in mice. As either oral GlcNAc or BCAA in mice are known to increase insulin resistance and weight gain, we note that recently published molecular data argues for a cooperative interaction.
佩德森等人（Pedersen HK、古德蒙松德特 V、尼尔森 HB、海约泰莱宁 T、尼尔森 T、延森 BA、福斯伦德 K、希尔德布兰德 F、普里夫蒂 E、法洛尼 G 等人，2016 年。人类肠道微生物影响宿主血清代谢组和胰岛素敏感性。自然。535:376-381.）报告称，人类血清中支链氨基酸（BCAA）和 N-乙酰葡萄糖胺（GlcNAc）的水平与胰岛素抵抗成正比增加。他们专注于微生物组及其相关的微生物物种亚群，从而在小鼠中证明了疾病的因果关系。由于众所周知，小鼠口服 GlcNAc 或 BCAA 会增加胰岛素抵抗和体重增加，我们注意到最近发表的分子数据表明存在协同作用。
