Ma Yao, Wang Ying-Jun, Chen Bing-Rui, Shi Hao-Jie, Wang Hao, Khurwolah Mohammad Reeaze, Li Ya-Fei, Xie Zhi-Yong, Yang Yang, Wang Lian-Sheng
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Division of Cardiology, Sheyang County People's Hospital, Yancheng, China.
PLoS One. 2017 Oct 19;12(10):e0185598. doi: 10.1371/journal.pone.0185598. eCollection 2017.
To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population.
A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD.
Compared with non-employed people, long working hours (especially ≥55 hours/week) contributed to the occurrence of CHD (adjusted odds ratio[OR] = 2.213, 95% confidence interval [CI]: 1.125, 4.355, P = 0.021) after multivariate adjustment in the Chinese population. With the extension of worktime, the CHD risk increased (P for the dose-response trend = 0.022). Meanwhile, even after adjusting for engagement in physical activity during leisure time, sedentary behavior at work had an adverse effect on CHD risk (adjusted OR = 2.794, 95%CI: 1.526, 5.115, P = 0.001), and a linear relationship was also found between OPA and CHD (P for the trend = 0.005).
Long working hours and sedentary behavior at work are associated with a high risk of CHD. In addition, prolonged working hours in sedentary occupations increases the risk of CHD, independent of engagement in leisure time physical activity.
探讨中国人群中工作时长和职业体力活动（OPA）与冠心病（CHD）发生之间的关联。
2015年12月至2016年10月期间，在南京医科大学第一附属医院开展了一项研究，共纳入595名年龄在24至65岁之间的参与者（分别为354例冠心病患者和241例无冠心病患者）。通过面对面问卷调查收集参与者的特征，并进行逻辑回归分析，以检验工作时长和OPA与冠心病发生之间的关联。
在中国人群中，经过多因素调整后，与未就业者相比，长时间工作（尤其是每周≥55小时）会增加冠心病的发生风险（调整后的优势比[OR]=2.213，95%置信区间[CI]：1.125，4.355，P=0.021）。随着工作时间的延长，冠心病风险增加（剂量反应趋势的P值=0.022）。同时，即使在调整了休闲时间的体力活动参与情况后，工作时的久坐行为对冠心病风险仍有不利影响（调整后的OR=2.794，95%CI：1.526，5.115，P=0.001），并且还发现OPA与冠心病之间存在线性关系（趋势的P值=0.005）。
长时间工作和工作时的久坐行为与冠心病的高风险相关。此外，久坐职业中工作时间的延长会增加冠心病风险，且独立于休闲时间的体力活动参与情况。
