中国人群中与运动相关的体力活动时间与急性心肌梗死发病之间的关联
Association between Time of Day of Sports-Related Physical Activity and the Onset of Acute Myocardial Infarction in a Chinese Population.
作者信息
Zhao Shan, Zhang Zhen, Long Qingqing, Ma Yao, Lian Xiaoqing, Yang Yang, Gao Wei, Chen Zhong, Wang Liansheng
机构信息
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, 200233,China.
出版信息
PLoS One. 2016 Jan 11;11(1):e0146472. doi: 10.1371/journal.pone.0146472. eCollection 2016.
OBJECTIVE
To investigate the association between the time of day of sports-related physical activity and the onset of acute myocardial infarction (AMI) in a coronary artery disease (CAD) population in China.
METHODS
Between February 2014 and March 2015, a total of 696 patients from Nanjing, China, who had CAD were studied and divided into two groups (Non-AMI and AMI groups). The work-related activity and sports-related physical activity information were obtained from a self-reporting predesigned patient questionnaire.
RESULTS
Sports-related physical activity was associated with a lower risk of the onset of AMI, after adjusting the established and potential confounders, with an adjusted odds ratio (OR) of 0.67 (95% CI, 0.47-0.94) compared with those who did not have any sports-related physical activity. A dose-response relationship was observed for intensity, duration, and frequency of sports-related physical activity. Further stratification analysis revealed that the protective effects of sports-related physical activity were significant in the morning and evening groups, and patients who exercised in the evening were at a lower risk of AMI than those doing sports-related physical activity in the morning. The adjusted ORs for doing sports-related physical activity in the morning and evening groups were 0.60(0.36-0.98) and 0.56(0.37-0.87), respectively, compared with inactivity (all P<0.05). On the occurrence of AMI, doing sports-related physical activity in the evening had an adjusted OR of 0.93 (95% CI, 0.54-1.64, P = 0.824) compared with in the morning group.
CONCLUSIONS
Sports-related physical activity is associated with a lower risk of onset of AMI than inactivity in Chinese people. For CAD patients, we suggest they participate in sports-related physical activity of high intensity, long duration, and high frequency. Doing sports-related physical activity in the evening and in the morning have similar benefits on the prevention of the onset of AMI.
目的
在中国冠心病（CAD）人群中，研究与运动相关的体力活动的时间与急性心肌梗死（AMI）发病之间的关联。
方法
2014年2月至2015年3月，对来自中国南京的696例CAD患者进行研究，并分为两组（非AMI组和AMI组）。通过预先设计的患者自填问卷获取与工作相关的活动和与运动相关的体力活动信息。
结果
在调整既定和潜在混杂因素后，与无任何与运动相关的体力活动者相比，与运动相关的体力活动与较低的AMI发病风险相关，调整后的比值比（OR）为0.67（95%CI，0.47 - 0.94）。观察到与运动相关的体力活动的强度、持续时间和频率存在剂量反应关系。进一步分层分析显示，与运动相关的体力活动的保护作用在早晨组和晚上组中显著，晚上进行运动的患者发生AMI的风险低于早晨进行与运动相关体力活动的患者。与不运动相比，早晨组和晚上组进行与运动相关体力活动的调整后OR分别为0.60（0.36 - 0.98）和0.56（0.37 - 0.87）（均P<0.05）。在发生AMI方面，与早晨组相比，晚上进行与运动相关体力活动的调整后OR为0.93（95%CI，0.54 - 1.64，P = 0.824）。
结论
在中国人群中，与运动相关的体力活动与比不运动更低的AMI发病风险相关。对于CAD患者，我们建议他们参加高强度、长时间和高频次的与运动相关的体力活动。早晨和晚上进行与运动相关的体力活动对预防AMI发病具有相似的益处。
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