Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
Patient and Family Wellness Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center.
J Pediatr Psychol. 2018 Mar 1;43(2):172-184. doi: 10.1093/jpepsy/jsx104.
To develop and pilot test a discrete choice experiment (DCE) to assess the specific factors likely to motivate a given adolescent or young adult with cancer to adhere to medications included in treatment protocols.
A multimethod and iterative approach was used. Twenty adolescents and young adults with cancer participated in DCE pilot testing and refinement. Hierarchical Bayes was used to estimate attribute and attribute-level preference scores for each participant.
The final DCE included nine choice sets composed of four attributes. The resulting DCE was modified with feedback from 20 adolescents and young adults (M[SD] age = 18.66 [2.95]) with cancer. The DCE was understandable and relevant. The factors likely to motivate adolescents and young adults with cancer to be adherent differed across individuals.
DCEs including the measure developed in this manuscript offer a novel approach to understanding individual-level differences critical for informing adherence-promotion efforts.
开发并试点测试一项离散选择实验（DCE），以评估可能促使特定癌症青少年或青年患者坚持治疗方案中包含的药物的具体因素。
采用多方法和迭代方法。20 名癌症青少年和年轻人参与了 DCE 的试点测试和改进。分层贝叶斯用于估计每个参与者的属性和属性级别偏好得分。
最终的 DCE 包括由四个属性组成的九个选择集。根据 20 名癌症青少年和年轻人（M[SD]年龄=18.66 [2.95]）的反馈对 DCE 进行了修改。DCE 易于理解且相关。可能促使癌症青少年和年轻人坚持治疗的因素因个体而异。
包括本文中开发的测量方法在内的 DCE 为理解关键的个体差异提供了一种新方法，这些差异对于告知坚持治疗的努力至关重要。
