Gubbi Sriram, Schwartz Elianna, Crandall Jill, Verghese Joe, Holtzer Roee, Atzmon Gil, Braunstein Rebecca, Barzilai Nir, Milman Sofiya
Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York; Department of Internal Medicine, Jacobi Medical Center, Bronx, New York.
Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York.
Am J Cardiol. 2017 Dec 15;120(12):2170-2175. doi: 10.1016/j.amjcard.2017.08.040. Epub 2017 Sep 18.
Offspring of parents with exceptional longevity (OPEL) manifest lower prevalence of cardiovascular disease (CVD), but the role of lifestyle factors in this unique cohort is not known. Our study tested whether OPEL have lesser prevalence of CVD independent of lifestyle factors. Prevalence of CVD and CVD risk factors was assessed in a population of community-dwelling Ashkenazi Jewish adults aged 65 to 94 years. Participants included OPEL (n = 395), defined as having at least 1 parent living past the age of 95 years, and offspring of parents with usual survival (OPUS, n = 450), defined as having neither parent survive to 95 years. Medical and lifestyle information was obtained using standardized questionnaires. Socioeconomic status was defined based on validated classification scores. Dietary intake was evaluated with the Block Brief Food Frequency Questionnaire (2000) in a subgroup of the study population (n = 234). Our study found no significant differences in the prevalence of obesity, smoking, alcohol use, physical activity, social strata scores, and dietary intake between the 2 groups. After adjustment for age and gender, the OPEL demonstrated 29% lower odds of having hypertension (95% confidence interval [CI] 0.53 to 0.95), 65% lower odds of having had a stroke (95% CI 0.14 to 0.88), and 35% lower odds of having CVD (95% CI 0.43 to 0.98), compared with OPUS. In conclusion, exceptional parental longevity is associated with lower prevalence of CVD independent of lifestyle, socioeconomic status, and nutrition, thus highlighting the potential role of genetics in disease-free survival among individuals with exceptional parental longevity.
父母长寿的后代（OPEL）患心血管疾病（CVD）的患病率较低，但生活方式因素在这一独特队列中的作用尚不清楚。我们的研究测试了OPEL是否独立于生活方式因素而具有较低的CVD患病率。在65至94岁的社区居住的阿什肯纳兹犹太成年人中评估了CVD和CVD危险因素的患病率。参与者包括OPEL（n = 395），定义为至少有1位父母活到95岁以上，以及父母正常存活的后代（OPUS，n = 450），定义为父母均未活到95岁。使用标准化问卷获取医疗和生活方式信息。根据经过验证的分类评分定义社会经济地位。在研究人群的一个亚组（n = 234）中，使用Block简短食物频率问卷（2000）评估饮食摄入量。我们的研究发现，两组之间在肥胖、吸烟、饮酒、身体活动、社会阶层评分和饮食摄入量方面没有显著差异。在调整年龄和性别后，与OPUS相比，OPEL患高血压的几率降低了29%（95%置信区间[CI] 0.53至0.95），患中风的几率降低了65%（95%CI 0.14至0.88），患CVD的几率降低了35%（95%CI 0.43至0.98）。总之，父母的超长寿命与较低的CVD患病率相关，且独立于生活方式、社会经济地位和营养，从而突出了遗传学在父母超长寿命个体无病生存中的潜在作用。
