Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China.
Clin Chim Acta. 2017 Dec;475:85-90. doi: 10.1016/j.cca.2017.10.012. Epub 2017 Oct 16.
Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a series of adverse complications that cause so-called AF socioeconomic burden. Apart from the classical risk factors, it seems to be novel factors that increase the risk of AF and AF-related stroke. Recently, more and more evidence has well documented the close relationships between homocysteine (Hcy) and AF. As a well-known marker for pro-oxidation and pro-inflammation, Hcy plays an important role in a number of vascular diseases having strong association with AF. This review will discuss the expression of Hcy and its association with ischemic stroke in AF patients especially for elderly patients, and the role and clinical implications of Hcy in the thromboembolic events and rhythm outcome in AF patients. The possible mechanisms linking elevated Hcy and cardiovascular events in AF patients will also be addressed, including oxidative stress, inflammatory response, atrial remodeling, etc.
心房颤动（AF）是最常见的持续性心律失常，与一系列不良并发症有关，这些并发症导致了所谓的 AF 社会经济负担。除了经典的危险因素外，似乎还有一些新的因素会增加 AF 和 AF 相关中风的风险。最近，越来越多的证据充分证明了同型半胱氨酸（Hcy）与 AF 之间的密切关系。作为一种众所周知的促氧化和促炎标志物，Hcy 在许多血管疾病中发挥着重要作用，与 AF 有很强的关联。这篇综述将讨论 Hcy 的表达及其与 AF 患者（特别是老年患者）缺血性中风的关系，以及 Hcy 在 AF 患者血栓栓塞事件和节律结果中的作用及其临床意义。还将讨论将升高的 Hcy 与 AF 患者心血管事件联系起来的可能机制，包括氧化应激、炎症反应、心房重构等。
