Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neurology, NeuroCure Clinical Research Center, Berlin, Germany; Department of Neurology, Universitätsmedizin Greifswald, Greifswald, Germany.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neurology, NeuroCure Clinical Research Center, Berlin, Germany.
Neurobiol Aging. 2018 Jan;61:245-254. doi: 10.1016/j.neurobiolaging.2017.09.017. Epub 2017 Sep 28.
Strategies for memory enhancement, especially for the older population, are of great scientific and public interest. Here, we aimed at investigating neuronal and behavioral effects of transcranial direct current stimulation (tDCS) paired with memory training. Young and older adults were trained on an object-location-memory task on 3 consecutive days with either anodal or sham tDCS. Recall performance was assessed immediately after training, 1 day and 1 month later, as well as performance on trained function and transfer task. Resting-state functional magnetic resonance imaging was conducted at baseline and at 1-day follow-up to analyze functional coupling in the default mode network. Anodal tDCS led to superior recall performance after training, an associated increase in default mode network strength and enhanced trained function and transfer after 1 month. Our findings suggest that tDCS-accompanied multi-day training improves performance on trained material, is associated with beneficial memory network alterations, and transfers to other memory tasks. Our study provides insight into tDCS-induced behavioral and neuronal alterations and will help to develop interventions against age-related cognitive decline.
增强记忆的策略，特别是针对老年人群体，具有重要的科学和公共利益。在这里，我们旨在研究经颅直流电刺激（tDCS）与记忆训练相结合对神经元和行为的影响。年轻和老年成年人在连续 3 天内接受物体-位置记忆任务的训练，分别接受阳极或假 tDCS。在训练后、1 天和 1 个月后立即评估回忆表现，以及在训练功能和转移任务上的表现。在基线和 1 天随访时进行静息态功能磁共振成像，以分析默认模式网络中的功能耦合。阳极 tDCS 导致训练后回忆表现更好，与默认模式网络强度增加相关，并在 1 个月后增强了训练功能和转移。我们的研究结果表明，tDCS 伴随的多日训练可以提高对训练材料的表现，与有益的记忆网络改变相关，并转移到其他记忆任务。我们的研究为 tDCS 诱导的行为和神经元改变提供了深入的了解，并将有助于开发针对与年龄相关的认知衰退的干预措施。
