Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Semin Cell Dev Biol. 2018 Sep;81:141-148. doi: 10.1016/j.semcdb.2017.10.012. Epub 2017 Oct 24.
Milk lipids provide a large proportion of energy, nutrients, essential fatty acids, and signaling molecules for the newborns, the synthesis of which is a tightly controlled process. Dysregulated milk lipid production and composition may be detrimental to the growth, development, health and survival of the newborns. Many genetically modified animal models have contributed to our understanding of milk lipid regulation in the lactating mammary gland. In this review, we discuss recent advances in our knowledge of the mechanisms that control milk lipid biosynthesis and secretion during lactation, and how maternal genetic and dietary defects impact milk lipid composition and consequently offspring traits.
牛奶脂质为新生儿提供了大量的能量、营养物质、必需脂肪酸和信号分子，其合成是一个严格控制的过程。牛奶脂质的产生和组成失调可能对新生儿的生长、发育、健康和生存有害。许多基因修饰动物模型有助于我们了解泌乳乳腺中牛奶脂质的调节。在这篇综述中，我们讨论了在泌乳期间控制牛奶脂质生物合成和分泌的机制的最新进展，以及母系遗传和饮食缺陷如何影响牛奶脂质组成，进而影响后代特征。
