Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.
Microb Pathog. 2017 Dec;113:282-285. doi: 10.1016/j.micpath.2017.10.014. Epub 2017 Oct 16.
Cytomegalovirus (CMV) infection during pregnancy is far more complex than other infections, due to ability of the virus to be frequently reactivated during the child bearing age and may vertically transmitted to the developing fetus in spite of maternal immunity. Therefore, in the current study we determined the prevalence of CMV infection in pregnant women and tried to identify the role of maternal CMV infection in adverse pregnancy outcomes in Northern India. In this case-control study, 517 pregnant women, out of them 200 in case group and 317 in the control group. The overall 31.72% (164/517) cases were found with active CMV infection. CMV positivity (p=0.026) was significantly associated with bad obstetric history (75/200, 37.50%) compared to normal pregnancy (89/317, 28.07%). CMV infection was predominantly observed in age group 21-25 years. CMV positivity have been found to be significantly higher in women from rural area as compare to those from urban area (p=0.028). However, no significant difference has been observed in case of occupation, income, and haemoglobin level.
巨细胞病毒（CMV）感染在怀孕期间比其他感染更为复杂，因为病毒在生育年龄期间经常被重新激活，并且尽管有母体免疫力，仍可能垂直传播给发育中的胎儿。因此，在目前的研究中，我们确定了孕妇中 CMV 感染的流行率，并试图确定母体 CMV 感染在印度北部不良妊娠结局中的作用。在这项病例对照研究中，517 名孕妇中，200 名在病例组，317 名在对照组。总体而言，发现 31.72%（164/517）的病例存在活动性 CMV 感染。与正常妊娠（89/317，28.07%）相比，CMV 阳性（p=0.026）与不良产科史（75/200，37.50%）显著相关。CMV 感染主要发生在 21-25 岁年龄组。与来自城市地区的妇女相比，来自农村地区的妇女的 CMV 阳性率显著更高（p=0.028）。然而，在职业、收入和血红蛋白水平方面，没有观察到显著差异。
